Zila, Inc.

Zila Biotechnology, Inc.

Douglas D Burkett

Ralph E Green

Samuel D Bernal

Photochemical demethylation reactions in solutions of thiazine dyes, in which the dye molecules act as both sensitizer and substrate, are reduced by quenching triple-state dye molecules, returning them to the unreactive ground state.

Light stabilized in vivo stain composition and method of manufacture

The location at which tissue samples are obtained to determine whether cells exhibit characeristics associated with cell differentiation or cancer by molecular analysis is determined by topically applying to epithelial tissue a dye that selectively stains cancer and precancerous tissue.

Stain-directed molecular analysis for cancer prognosis and diagnosis

Light-stabilized(in vivo) stain composition and method of manufacture

In diagnostic testing for cancer and precancer of the epithelium, the undesired binding of cancer-selective dyes to proteins in the extracellular matrix, which may lead to false positives, is reduced by applying to the epithelium being tested, before application of the dye, a solution of a non-toxic amphiphilic protein in a pharmacolgically acceptable solvent.

Diagnostic method for detecting dysplastic epithelial tissue

Compounds having the structural formula (A) wherein X is hydrogen, methyl, or Y; Y is &mdash;NH&mdash;R or hydrogen; and R is methyl or formula (B) are useful as in vivo stains for the detection of dysplastic tissue.

In Vivo stain compounds and methods of use to identify dysplastic tissue

A diagnostic method for detecting cancerous epithelial cells by selectively marking the mitochondria of the cancer cells, by delivering to the epithelium a cationic supravital mitochondrial marking agent. Selective killing of cancerous epithelial cells in the presence of normal cells is effected by delivering a cationic supravital mitochondrial marking agent to epithelial cancer cells. The killing agent can also comprise the reaction product of the marking agent and a cancer chemotherapeutic drug.

Method for detecting and killing epithelial cancer cells

A process for synthesizing 2-amino-5-dimethlyaminophenyl thiosulfonic acid comprises the step of oxidizing N,N&prime;-dimethyl-&rgr;-phenylene-diamine in the presence of a source of thiosulfate ions, while maintaining the temperature of the reaction mixture not higher than about 10&deg; C. This compound is useful as an intermediate in the synthesis of toluidine blue O. A process for manufacturing toluidine blue O with improved yield, includes the step of preparing the intermediate 2-amino-5-diethylaminopropyl thiosulfonic acid according to the above described procedure.

Growing community of inventors

Gilbert, AZ, United States of America

Douglas D Burkett