Rhode Island Hospital

Prothera Biologics, Inc.

Rhode Island Hospital, a Lifespan-partner

Douglas C Hixson

Yow-Pin Lim

Djuro Josic

The invention relates to Inter-alpha inhibitor proteins (I&#x3b1;Ip). The invention further relates to processes for purification of I&#x3b1;Ip compositions and their use for treatment of human diseases such as sepsis and septic shock, rheumatoid arthritis, cancer and infectious diseases.

Preparation and composition of inter-alpha inhibitor proteins from human plasma for therapeutic use

The invention provides a method of diagnosing sepsis in a mammal by contacting a bodily fluid from the mammal with a ligand which binds to an inter-alpha trypsin inhibitor (ITI) polypeptide under conditions sufficient to form an ITI-ligand complex and detecting the complex.

Inter-alpha-trypsin inhibitor as a marker for sepsis

A method for diagnosing a tumor in the central nervous system of a mammal is carried out by contacting a bodily fluid from the mammal with a ligand which binds to inter-alpha trypsin inhibitor.

Methods for detecting cancer of the central nervous system

A preparative electrophoresis device having a pair of spaced apart plates, a pre-cast electrophoretic gel between the plates, and a semipermeable membrane sealably connected to ends of the plates to define with the plates a collection channel for receiving molecules that have traveled through the gel. Also disclosed are close spacing (less than 2.0 mm) of the plates, an inlet tube and an outlet tube connected to the two plates and communicating with opposite ends of the collection channel, an elongated divider between the plates to divide the gel into a purification region and an indicating region that is not as wide as the purification region and receives marker molecules of known molecular weight to indicate the location in the indicating region of molecules of interest, and pumping electrophoretic buffer into the collection channel at the same rate that it is pumped out.

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Barrington, RI, United States of America

Douglas C Hixson