Huntington Medical Research Institutes

Huntington Medical Research Institute

Huntingdon Medical Research Institutes

Douglas B McCreery

Leo A Bullara

Stephen H Waldron

Marylou Ingram

William F Agnew

Martin Han

Ted G Yuen

An intraoral stimulation device configured to be positioned in a mouth of a patient. The device includes a sensor and one or more electrodes. The sensor is configured to monitor a position of the tongue and/or force exerted by the tongue against the sensor and to transmit a signal encoding tongue information. The electrode(s) is/are configured to deliver electrical stimuli to the patient's hard palate when the tongue information indicates that the tongue has moved from a desired position to an undesired position in the mouth. The electrical stimuli causes the tongue to move from the undesired position to the desired position.

Methods and devices for treating sleep apnea

The invention relates to a multielectrode probe having a silicon substrate which supports multiple conductive electrodes for deep-brain electrical stimulation or recording of neural responses. The substrate has an upper end with multiple conductive portions for bonding to lead wires, and an elongated shank extends from the upper end. The shank supports multiple spaced-apart electrodes, typically ten in number, and conductive traces electrically connect the electrodes and conductive traces. Multiple probes are combined, and supported as an array by a cylindrical alignment cylinder.

Microelectrode array for chronic deep-brain microstimulation for recording

The present invention describes an apparatus, a system and a method for the treatment of obstructive sleep apnea. The treatment involves monitoring the position of the tongue and/or the force exerted by the tongue and electrical stimulation of the hypoglossal nerve to move the tongue into an anterior position or to maintain the tongue in an anterior position.

Apparatus and method for treating obstructive sleep apnea

A tool for inserting medical electrodes such as nerve-stimulating electrodes into tissue. An electrode is positioned fully within a tip of the tool so the tip end can be placed directly against the tissue to be penetrated for precise handheld positioning. A trigger on the tool is actuated to release a compressed spring in the tool to drive the electrode out of the tool tip into the target tissue. A viscous-damping means is provided in the tool to control electrode acceleration and velocity.

Electrode insertion tool

Iridium electrodes of very small diameter such as 35 microns are formed from larger-diameter commercially available iridium wire by an electrolytic etching process. A saturated solution of sodium chloride in a preferred etching solution. The electrodes are formed with sharp conical tips which can be rounded or blunted if desired by additional etching. Platinum lead wire is welded to the electrode shank, and the electrode is coated with an insulating varnish which is ablated at the electrode tip to expose a conductive surface.

Methods for making small-diameter iridium electrodes

The invention is a method of attracting lymphocytes to at least one desired location in the body of a patient for a therapeutic purpose (e.g., treating infection or inflammation, killing tumor cells, etc.), the method comprising contacting the desired location with one or more electrodes and stimulating the tissue with current at an intesity below that which will physically damage the cells, yet sufficient to attract lymphocytes.

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Pasadena, CA, United States of America

Douglas B McCreery