Millennium Pharmaceuticals Limited

Cytrellis Biosystems, Inc.

Seventh Sense Biosystems, Inc.

Transform Pharmaceuticals, Inc.

Other

T2 Biosystems, Inc.

Millennium Biotherapeutics, Inc.

Yourbio Health, Inc.

Fount Bio, Inc.

Douglas Adam Levinson

Alec Ginggen

Howard Bernstein

Donald E Chickering, Iii

Ramin Haghgooie

Shawn Davis

David A Stone

Javier Gonzalez-Zugasti

Mark Michelman

Richard L Miller

Christopher John Morse

David P Gearing

Scott W James

Sean Anthony McCarthy

Carlos J Gimeno

A David Boccuti

Maisam Dadgar

Greg Fisher

Michael John Cima

David R Walt

Örn Almarsson

Anthony Lemmo

Alasdair Y Johnson

Christopher McNulty

Robert Samuel Langer

Kristian J DiMatteo

David Arthur Berry

Thomas Swyst

Thomas Jay Lowery, Jr

Samir Suresh Mitragotri

Tuan A Elstrom

Mark John Audeh

Oivind Brockmeier

Ping Gong

Nicholas Anderson

Douglas R Vogus

Eric Spengler

James Joseph Koziarz

Sonia Kumar

Robert Brik

Timothy M Blicharz

Jose Lizardi

Nick Anderson

Donald E Iii Chickering

Doanld E Chickering

David Stone

Christopher Mcnulty

Christine Kitsos

Irena Melnikova

The present application describes to the synthesis, formulation and uses of crosslinkable entities and crosslinked materials.

Crosslinked materials

Disclosed herein are apparatuses, systems, kits, and methods for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning and/or for generally improving skin function or appearance (e.g., the removal of unwanted skin features or irregularities such as sebaceous glands, sweat glands, hair follicles, necrosis, and fibrosis). Such apparatuses, systems, kits, and methods comprise an apparatus having a handheld main body and a detachably attachable tip comprising one or more needles.

Devices and methods for ablation of the skin

Disclosed herein are methods, apparatuses, and devices for treating skin, such as skin tightening or for treating diseases, disorders, and conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, or skin repositioning. Such methods and devices include an ablative apparatus, a removal apparatus, and/or a positioning apparatus.

Methods and apparatuses for skin treatment using non-thermal tissue ablation

The present invention relates to methods and devices for skin tightening after incising or excising tissue portions from a subject. Exemplary methods and devices include tunable dressings having an adhesive layer and a regulatable layer or an un-stretched layer that responds to one or more external stimuli to contract or expand the dressing, where the contraction or expansion can be uniform or non-uniform.

Methods and devices for skin tightening

The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species. However, the feedback may also be indirect in some embodiments.

Systems and techniques for monitoring subjects

Disclosed herein are apparatuses, kits, and methods for treating skin, such as skin tightening, e.g., reducing skin laxity, for treating conditions that would benefit from tissue area or volume reduction, skin restoration, skin tightening, skin lifting, and/or skin repositioning, and/or for generally improving skin function or appearance. Such apparatuses, kits, and methods include one or more hollow needles each having at least one prong and a mechanism for removing skin tissue portion(s) from the hollow needle(s).

Devices and methods for cosmetic skin resurfacing

The present invention features methods of manipulating subdermal fat in a treatment area. Such methods include inserting a needle (e.g., a micro-coring needle) through the dermis to the subdermal fat layer in order to excise a portion of tissue from the treatment area. These insertions result in a portion of the dermis and a portion of subdermal fat to enter into the needle. Removal of the needle results in excision of the portion of dermis and subdermal fat that entered into the needle.

Methods and devices for manipulating subdermal fat

The present invention generally relates to devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications, for example, devices for delivering and/or withdrawing fluid from subjects, e.g., through the skin. In some embodiments, the device includes a system for accessing an extractable medium from and/or through the skin of the subject at an access site, and a pressure regulator supported by a support structure, able to create a pressure differential across the skin at at least a portion of the access site. The device may also include, in some cases, a sensor supported by the support structure for determining at least one condition of the extractable medium from the subject, and optionally a signal generator supported by the support structure for generating a signal relating to the condition of the medium determined by the sensor.

Techniques and devices associated with blood sampling

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

Delivering and/or receiving fluids

Growing community of inventors

Sherborn, MA, United States of America

Douglas Adam Levinson