Cardiome Pharma Corp.

Terramera, Inc.

Correvio International Sàrl

Doug Ta Hung Chou

Bertrand M C Plouvier

Gregory N Beatch

Grace Jung

Lewis Siu Leung Choi

James Gee Ken Yee

Tao Sheng

Anthony G M Barrett

Allen Davidoff

Aregahegn Yifru

Alfred Hedinger

Pirmin Ulmann

Marco Silvio Passafaro

Martin Kurz

Daniel Moeckli

Jeff Jiqun Zhu

Yuzhong Liu

Peter Pang

Steven Chun Hon Lin

Hangsheng Li

Alan M Ezrin

Lewis S L Choi

Jeffery Jerome Wheeler

Jeffrey Jerome Wheeler

Adewale Eniade

Bertrand Mc Plouvier

Elizabeth L S Cheu

Betrand Mc Plouvier

Richard Wall

Bertrand Plouvier

Marco S Passafaro

Anthony GM Barrett

Anthony GM Barett

Pesticidal compositions for improving physical characteristics of pesticide formulations which comprise natural pesticidal oil active ingredients are disclosed. One such composition comprises a pesticidal natural oil active ingredient, a surfactant to disperse the active ingredient in a water emulsion and a polymeric pour point depressant effective to reduce a pour point temperature of the pesticidal natural oil active ingredient. Methods for providing pesticidal compositions and application to control one or more pests are also disclosed.

Pesticidal compositions with improved physical characteristics

Pesticidal compositions for improving physical characteristics of pesticide formulations which comprise natural pesticidal oil active ingredients are disclosed. One such composition comprises a pesticidal natural oil active ingredient, a surfactant to disperse the active ingredient in a water emulsion, a polymeric pour point depressant effective to reduce a pour point temperature of the pesticidal natural oil active ingredient and a hydrocarbon solvent. Methods for providing pesticidal compositions and application to control one or more pests are also disclosed.

Natural oil pesticidal compositions

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed.

Synthetic process for aminocyclohexyl ether compounds

Methods for the preparation of stereoisomerically substantially aminocyclohexyl ether compounds such as trans-(1R,2R)-aminocyclohexyl ether compounds and/or trans-(1S,2S)-aminocyclohexyl ether compounds as well as various intermediates and substrates are disclosed. 

This invention is directed to stereoselective synthesis of compounds of formula (I) or formula (II): or a pharmaceutically acceptable salt, ester, amide, complex, chelate, clathrate, solvate, polymorph, stereoisomer, metabolite or prodrug thereof; wherein R, Rand Rare defined herein. Compounds of formula (I) and formula (II) are known to be useful in treating arrhythmias.

Synthetic processes for the preparation of aminocyclohexyl ether compounds

Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.

Aminocyclohexyl ether compounds and uses thereof

Merged compounds of ion channel modulating compounds, including, for example, merged compounds of the ion channel modulating compound of the following formula: (I) are described herein, as well as methods of making and using such merged compounds and pharmaceutical compositions containing such merged compounds. 

Merged ion channel modulating compounds and uses thereof

This invention is directed to deuterated aminocyclohexyl ether compounds and processes for preparing same and methods of using same.

Deuterated aminocyclohexyl ether compounds and processes for preparing same

Prodrugs of ion channeling modulating compounds, including, for example, prodrugs of the ion channel modulating compound of the following formula: are described herein, as well as methods of making and using such prodrugs and pharmaceutical compositions containing such prodrugs. 

Prodrugs of ion channel modulating compounds and uses thereof

This invention is directed to drug conjugates of certain ion channel modulating compounds having the following formula: wherein A, X, R, R, R, R, R, LB, L and DM are defined herein, including isolated enantiomeric and diastereomeric isomers thereof, and mixtures thereof. Pharmaceutical compositions and methods of use are also disclosed.

Drug conjugates of ion channel modulating compounds

Growing community of inventors

Vancouver, Canada

Doug Ta Hung Chou