University of Texas System

Doug E Frantz

Jay Schneider

Steven L McKnight

Jenny Hsieh

Eric N Olson

Joseph Ready

Melanie H Cobb

Hector Aguilar

Charles G Caldwell

Kevin H Gardner

Richard Keith Bruick

John B MacMillan

Uttam K Tambar

Thomas H Scheuermann

Elhadji Dioum

Elhadij Dioum

Provided is a method of inhibiting heterodimerization of HIF-2&#x3b1; to HIF1&#x3b2; (ARNT) comprising binding certain small molecules to the HIF-2&#x3b1; PAS-B domain cavity but not to HIF1&#x3b1; and inhibiting HIF-2&#x3b1; heterodimerization to HIF1&#x3b2; (ARNT) but not inhibiting HIF1&#x3b1; heterodimerization to HIF1&#x3b2; (ARNT). Those certain small molecules are also referenced synonymously as HIF2-HDI and HIF2&#x3b1; heterodimerization inhibitors and also simply as certain small molecules.

Inhibition of HIF-2&#x3b1; heterodimerization with HIF1&#x3b2; (ARNT)

The present invention relates to compounds and methods for inducing synthesis and secretion of insulin from pancreatic beta cells. The methods may take place in vitro, ex vivo such as in isolates from adult mammalian tissue, or in vivo. Compounds and methods described herein may find use in the treatment of diabetes.

Isoxazole treatments for diabetes

The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Chemical inducers of neurogenesis

The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.

Stem cell differentiating agents and uses therefor

The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The compounds are isoxazole amides and derivatives thereof. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.

Isoxazole amides, derivatives and methods of chemical induction of neurogenesis

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Boerne, TX, United States of America

Doug E Frantz