Depuy Synthes Products, Inc.

Affinergy Inc.

Synthes Usa, LLC

Synthes Gmbh

Doug Buechter

Elliott A Gruskin

Hanne Gron

Stephen Hornsby

Melissa Brown

Paul Theodore Hamilton

Michael Lehmicke

Shrikumar Ambujakshan Nair

Martyn Kerry Darby

Isaac Gilliam Sanford

R Edward Benson

Meredith Hans Moore

Lisa Hughes

Meredith Hans-Moore

Meredith Hans

David Duffin

Isaac G Sanford

Invention embodiments described herein include methods and devices for stimulating mesenchymal stem cells in a stem cell source to differentiate into osteoblasts capable of forming bone. Devices and methods described include exposing a stem cell source, such as bone marrow aspirate, adipose tissue and/or purified allogenic stem cells, to an active agent, in a manner effective to form activated stem cells.

Method and device for activating stem cells

The present disclosure describes an implant for improving bone growth including an osteoconductive scaffold and an osteoinductive small molecule. The osteoconductive scaffold can further include a polymeric binder. The implant can also include an osteogenic material to provide a viable cell population to assist the bone repair and remodeling. Also disclosed is a system for forming an implant for improving bone growth, as well as methods for forming the implant according to the disclosure, in addition to methods of therapeutic use of the implant.

Osteogenic promoting implants and methods of inducing bone growth

The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.

Compositions and methods for delivery of glycopeptide antibiotics to medical device surfaces

Compositions are provided comprising a family of peptides having binding specificity for bone, and their use to produce coating compositions. The coating compositions are used to deliver a pharmaceutically active agent to bone, and are used in methods related to bone implants, bone repair, and bone-related diseases.

Methods and compositions for promoting localization of pharmaceutically active agents to bone

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Chester Springs, PA, United States of America

Doug Buechter