Arthrex, Gmbh

Cohera Medical, Inc.

Dottie M Clower

Eric John Beckman

Bradd N Picone

Despina Dobbins

Stephanie Kladakis

A composition that includes (a) a prepolymer having at least one free isocyanate group that is capable of bonding to tissue and that cures in vivo upon exposure to water to form a polymer having a compressive modulus between 1.9 and 14.4 MPa and a tensile modulus between 5.0 and 30, and (b) an oil that is miscible in the prepolymer, the oil being selected from the group consisting of silicone oils, mineral oil, vegetable oils, and combinations thereof. The composition retains its integrity when delivered in an aqueous medium.

Meniscal repair adhesive

A tissue sealant that includes the reaction product of (a) a polyol; (b) a polyisocyanate; and (c) an alkoxy silane having the formula: (RRR)&#x2014;Si&#x2014;CH&#x2014;Z where (i) Z is an &#x2014;OH, &#x2014;SH, &#x2014;NCO, or &#x2014;NHRgroup, where Ris hydrogen, an alkyl group, or an aryl group; and (ii) each R, R, and R, independently, is H, an alkoxy group, an alkyl group, a heteroalkyl group other than an alkoxy group, an aryl group, or a heteroaryl group, with the proviso that at least two of R, R, and Rare alkoxy groups, the relative amounts of the polyol, polyisocyanate, and alkoxy silane being selected such that the reaction product comprises free isocyanate groups. The tissue sealant is moisture-curable and biodegradable in a physiological environment.

Growing community of inventors

Pittsburgh, PA, United States of America

Dottie M Clower