Whitehead Institute for Biomedical Research

Dos D Sarbassov

David Sabatini

Do-Hyung Kim

The invention describes isolated mTOR-associated proteins ('mTOR-APs') as well as isolated variants and fragments thereof and the isolated nucleic acids encoding them. The invention also describes vectors and host cells containing nucleic acid encoding an mTOR-AP polypeptide and methods for producing an mTOR-AP polypeptide. Also described are methods for screening for compounds which modulate mTOR-AP activity and methods for treating or preventing a disorder that is responsive to mTOR-AP modulation.

Methods Relating to Mammalian Rictor Polypeptide

The present invention relates to isolated raptor nucleic acid molecules of mammalian origin (e.g., human) and complements, portions and variants thereof. Another aspect of the invention are isolated raptor polypeptides of mammalian origin and portions thereof, and antibodies or antigen binding fragments thereof that specifically bind a raptor polypeptide. The present invention also relates to constructs and host cells comprising the nucleic acid molecules described herein. In addition, the present invention relates to uses of the nucleic acid and polypeptide molecules provided herein.

Complexes comprising mammalian raptor polypeptide and mammalian mTOR polypeptide

Methods relating to mammalian raptor polypeptide

mTOR kinase-associated proteins

In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity.

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Shrewsbury, MA, United States of America

Dos D Sarbassov