The University of North Carolina at Chapel Hill

Dorothy H Wood

Richard Ray Tidwell

James E Hall

Pentamidine and analogs thereof have activity as imidazoline receptor binding compounds. A method of binding the imidazoline receptor, comprises contacting a bis-benzene to said imidazoline receptor in an amount effective to bind to said receptor, wherein said bis-benzene contains at least one amidine group (e.g., one or two). The contacting step may be carried out in vivo or in vitro. Contacting may be carried out with individual active compounds or with libraries of active compounds.

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Hillsborough, NC, United States of America

Dorothy H Wood