Gilead Sciences, Inc.

Dorothée Saddier Axe

William John Watkins

Chandrasekar Venkataramani

Peter A Blomgren

Musong Kim

Zhimin Du

Suet Chung Yeung

Julian Andrew Codelli

Gayatri Balan

Rhiannon Thomas-Tran

Gregg M Schwarzwalder

Helen Yu

Chen Chen

Michael T Tudesco

Brian M Weist

The present disclosure relates generally to compounds that bind to and act as degraders of an IKAROS Family Zinc Finger (IKZF) protein, such as IKZF2 (Helios) and/or IKZF4 (Eos). The disclosure further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding and degradation of an IKZF protein, such as IKZF2 and/or IKZF4, including cancer.

IKAROS Zinc Finger Family degraders and uses thereof

IKAROS zinc finger family degraders and uses thereof

Growing community of inventors

San Carlos, CA, United States of America

Dorothée Saddier Axe