Paladin Labs Inc.

Paladin Labs (barbados) Inc.

Paladin Labs Europe Limited

Dorothee Le Garrec

Damon Smith

Sonia Gervais

Miloud Rahmouni

Vinayak Sant

Ali Bichara

David Lessard

Sandra Gori

Laibin Luo

Francois Ravenelle

Patricia Ouadji

Shiva Gosein

Vincent Lemaire

Samir Taga

The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.

Solid formulations of liquid biologically active agents

The invention relates to a bilayer composition for the delivery of acetaminophen and tramadol over at least a twelve hour period following initial administration. A single administration of the bilayer composition can provide analgesia starting in less than half an hour to about one hour after initial administration with a duration of at least twelve hours after initial administration.

Bilayer composition for the sustained release of acetaminophen and tramadol

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Montreal, Canada

Dorothee Le Garrec