Universitéde Montreal

Doris Schuetz

Jacques Banville

Michael Dore

Joanne Tan

Pierre Louis Beaulieu

Yannick Rose

Eric Beaulieu

Mukund Ghavre

Sasmita Tripathy

Hugo Lavoie

Emeline Benoit

Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation. The compounds disclosed are of Formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, X, X, Xand Xare as defined herein.

Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease

Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation. The compounds disclosed are of Formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, X, X, Xand Xare as defined herein:

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Montréal, Canada

Doris Schuetz