Clariant Corporation

Hoechst Aktiengesellschaft

Doris Neumann-Grimm

Theodor Papenfuhs

Stefan Krause

Ralf Pfirmann

Andreas Dierdorf

Process for producing quinazoline derivatives

Monoesters of carboxymethylene anthranilic acids and process for

Process for preparing N-carboxymethylene-4-chloro-anthranilic acid and

The present invention relates to a process for the preparation of N-(2-carboxy-5-chloro-phenyl)glycine of the formula (1) ##STR1## which comprises reacting 2,4-dichlorobenzoic acid of the formula (2) ##STR2## with glycine and a base in water at a temperature of 50.degree. to 200.degree. C. in the presence of copper and oxygen at a pH of 7 to 13.

Process for the preparation of N-(2-carboxy-5-chloro-phenyl)glycine

Process for the preparation of N-carboxymethyleneanthranilic acid esters of the formula (3) ##STR1## by reacting a compound of the formula (1) ##STR2## in which R' is hydrogen or a straight-chain or branched alkyl radical having 1 to 4 carbon atoms and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and independently of one another are hydrogen, halogen, NO.sub.2, a straight-chain or branched alkyl, alkoxy or halogenated alkyl radical having in each case 1 to 6 carbon atoms, with a glyoxylic acid ester of the formula (2)

Process for the preparation of N-carboxymethyleneanthranilic acid

Growing community of inventors

Frankfurt-am-Main, Germany

Doris Neumann-Grimm