University of Virginia Patent Foundation

Doris M Haverstick

Lloyd S Gray

Timothy L MacDonald

Jaclyn R Patterson

William F McCalmont

Timothy L Macdonald

Gabor Szabo

Tiffany N Heady

John J Densmore

William F Mccalmont

The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein Ris C-Calkyl, hydroxy, or C-Calkoxy; Z is NH, NCH, O, S, or CH; Y is NH, O, or CHwith the proviso that Y and Z are not the same; Ris H, halo, NH, C-Calkyl, hydroxy, or C-Calkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and Ris H, halo, NH, C-Calkyl, hydroxy, or C-Calkoxy. 

T type calcium channel inhibitors

The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein

The present invention is directed to compounds useful as cancer cell inhibitors, compositions containing such compounds and methods for inhibiting proliferation of electrically non-excitable cells.

Anticancer calcium channel blockers

The present invention provides methods for screening for voltage gated (VG)-selective inhibitors, novel VG-selective inhibitors, compositions containing the same, methods for inhibiting calcium entry into electrically non-excitable cells with said VG-selective inhibitors, methods for preventing proliferation of electrically non-excitable cells with said VG-selective inhibitors as well as methods of treating autoimmune diseases, preventing graft rejections, preventing apoptosis and treating cancer with the same.

Growing community of inventors

Charlottesville, VA, United States of America

Doris M Haverstick