Mersana Therapeutics, Inc.

Dorin Toader

Timothy B Lowinger

Joshua D Thomas

Eugene W Kelleher

Marc I Damelin

Keith W Bentley

Jeremy R Duvall

Liping Yang

Brian D Jones

Naniye Cetinbas

Soumya S Ray

Raghida A Bukhalid

Ling Xu

Chen-Ni Chin

The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING). The present disclosure also provides uses of the ADCs in treatment, e.g., treatment of cancer.

Antibody drug conjugates comprising sting agonists

The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.

B7H4-targeted antibody-drug conjugates and methods of use thereof

The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.

Sting agonist compounds and methods of use

The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.

Site specific antibody-drug conjugates with peptide-containing linkers

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Cambridge, MA, United States of America

Dorin Toader