Janssen Sciences Ireland Unlimited Company

Ichor Medical Systems, Inc.

Dorien De Pooter

Soumitra Roy

Jean-Marc Edmond Fernand Marie Neefs

Daniel Boden

Helen Horton

Robert M Bernard

Andrew W Hannaman

Stephen A Morse

Adam Hartman

Thomas David Cox

Oliver Ruck

Methods and apparatus for the reproducible, consistent and efficacious delivery of an HBV vaccine to a subject. The disclosure comprises apparatus for the controlled administration of the HBV vaccine through an orifice to the subject, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and an electrical signal generator operatively connected to the electrodes.

Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines

Polynucleotides encoding hepatitis B virus (HBV) core antigen and polymerase antigen, and related combinations are described. Also described are vectors, such as DNA plasmids or viral vectors, expressing the HBV core and polymerase antigens, and immunogenic compositions containing the expression vectors. Methods of inducing an immune response against HBV or treating a HBV-induced disease, particularly in individuals having chronic HBV infection, using the immunogenic compositions are also described.

Hepatitis B virus (HBV) vaccines and uses thereof

Growing community of inventors

Veerle, Belgium

Dorien De Pooter