University of California

Bruker Cellular Analysis, Inc.

Dorian Liepmann

Albert P Pisano

Niren Murthy

Kiana Aran

Kunwoo Lee

Boris Stoeber

Jacobo Paredes

Eric D Hobbs

Mark P White

Joshua Tanner Nevill

Keith Joseph Breinlinger

John Evans

Kirk L Yerkes

Stefan Zimmermann

Maria Jimena Loureiro

Jeffrey Kirshberg

Ajay Deshmukh

Some configurations of a microfluidic apparatus can comprise a fluidic circuit of interconnected fluidic structures into which a plurality of different media can be introduced or extracted. A variety of operations can be performed with the different media including isolating with a second medium one or more of the fluidic structures that is filled partially or fully with a first medium. Discrete volumes of a medium can be moved through the isolating second medium to deliver materials or micro-objects to or remove micro-objects or materials from a fluidic structure that is otherwise isolated by the second medium. Some configurations of a microfluidic apparatus can isolate microfluidic structures in a microfluidic apparatus using flow rates or blocking structures, and some configurations can manage bubbles in fluidic structures.

Isolating microfluidic structures and trapping bubbles

Provided are active agent delivery devices configured to deliver an active agent formulation into or through a mucosal layer in a subject. The active agent delivery devices include a power reservoir configured to eject the active agent formulation at a pressure sufficient to deliver the active agent formulation into or through a mucosal layer in a subject. Methods of using the subject active agent delivery devices are also provided.

Active agent delivery devices and methods of using the same

A method and apparatus for substance monitoring. One application is an easy to handle continuous glucose monitor using a group of hollow out-of-plane silicon microneedles to sample substances in interstitial fluid from the epidermal skin layer. The glucose of the interstitial fluid permeates a dialysis membrane and reaches a sensor. Using MEMS technology, for example, allows well-established batch fabrication at low cost.

Monitoring method and/or apparatus

A microcapillary pumped loop (CPL) for chip level temperature control includes two mating substrates which define an evaporator, a condenser, and a reservoir for a liquid. A first substrate includes a vapor line which couples vapor from the evaporator to the condenser, and a liquid line which couples liquid from the condenser back to the evaporator. A wicking structure for the evaporator is formed by etching in the second substrate. The wicking structure couples the evaporator to the reservoir and to the liquid line. The condenser includes a plurality of grooves formed in the second substrate which couples liquid from the condenser to the liquid line.

MEMS microcapillary pumped loop for chip-level temperature control

A micro-electromechanical system and method for continuous laminar fluid mixing. An embodiment of the invention described in the specification includes a mixing channel, a first delivery channel that is connected to the mixing channel, and a second delivery channel that is connected to the mixing channel. A first pump mechanism produces pulses in the first delivery channel. A second pump mechanism produces pulses in the second delivery channel. The first pulsed fluid stream and the second pulsed fluid stream merge in the mixing channel to form a mixed fluid. The pulses in the fluids operate to distort the interface between the fluids to facilitate diffusion between the fluids.

Continuous laminar fluid mixing in micro-electromechanical systems

A method of forming a needle includes the step of anisotropically etching a channel into the back side of a semiconductor substrate. The front side of the semiconductor substrate is then isotropically etched to form a vertical axial surface surrounding the channel. The resultant needle has an elongated body formed of a semiconductor material. The elongated body includes an axial surface positioned between a first end and a second end. The axial surface defines a channel between the first end and the second end. In one embodiment, the first end has a sloping tip with a single circumferential termination point.

Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby

A microelectromechanical system mixes a fluid using predominantly planar laminar flow. The microelectromechanical system includes a mixing chamber and a set of valves to establish the planar laminar flow in the mixing chamber. In one embodiment, bubble-controlled pumps are operated with bubble-controlled valves to establish the predominantly planar laminar flow in the mixing chamber. The bubble-controlled pumps and valves may be used to establish a pulsed double-dipole flow field in the mixing chamber.

Growing community of inventors

Lafayette, CA, United States of America

Dorian Liepmann