Richter Gedeon Vegyeszeti Gyar Rt

Dora Groo

Laszlo Szporny

Eva Palosi

Bela Kiss

Istvan Laszlovszky

Erzsebet Lapis

Egon Karpati

Edit Toth

Jozsef Torley

Zsolt Szombathelyi

Tibor Keve

Bela Stefko

Istvan Hajdu

Gabor Megyeri

Ferenc Auth

Sandor Gorog

Ferenc Trischler

Janos Galambos

Erik Bogsch

Judit Laszy

Katalin Csomor

Aniko Gere

Adam Sarkadi

Mihaly Bodo

Laszlo Gaal

Zsolt Szentirmay

Csaba Szantay

Janos Kreidl

Laszlo Czibula

Bela Hegedus

Lajos Kovacs

Maria Farkas Nee Kirjak

Gyorgy Visky

Maria Zajer Nee Balazs

Bela Molnar

Judit M Meszaros Nee Brill

Andras Vedres

Karoly Nador

Istvan Moldvai

Anna Kassai Nee Zieger

Pal Scheiber

Nee Szelecsenyi Andrasi

Anna Kassainee Zieger

Bala Stefko

Anna Kassi Nee Zieger

Edith Toth

Jozsef Turley

Miklos Riesz

Laszlo Haal

The invention relates to novel 2-oxo-1-oxa-8-azaspiro[4,5]decane derivatives of the formula (I), ##STR1## wherein X means oxygen or an &gt;NR group, wherein

2-oxo-1-oxa-8 azaspiro[4,5]decane derivatives, pharmaceutical

The invention relates to, therapeutically active 2-oxo-3,8-diazaspiro[4,5]decane derivatives (I), ##STR1## wherein R means hydrogen, a C.sub.1-12 alkyl, C.sub.3-6 cycloalkyl, carbocyclic C.sub.6-10 aryl or carbocyclic C.sub.6-10 aryl-C.sub.1-4 alkyl group, the latter two optionally being substituted on their aromatic moiety by one or more, same or different halogen(s) or one or more C.sub.1-4 alkyl or C.sub.1-4 alkoxy group(s);

2-oxo-3,8-diazaspiro(4,5)decane derivatives, pharmaceutical compositions

The invention relates to novel, therapeutically active 4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives of the compound, ##STR1## wherein X means oxygen or an &gt;NR group, wherein

4-methylene-2-oxo-8-azaspiro[4,5]decane derivatives, pharmaceutical

The invention relates to novel compounds 1-oxa-2-oxo-8- of the formula (I), ##STR1## wherein X means oxygen or an &gt;NR group, wherein

1-oxa-2-oxo-8-azaspiro(4,5)decane derivatives, pharmaceutical

The invention relates to novel nitrogen- and sulfur-containing heterocyclic compounds of the formula (I), acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## Ar stands for an optionally mono- or polysubstituted aryl or heteroaryl group;

Heterocyclic compounds containing nitrogen and sulfur, pharmaceutical

The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and stand for hydrogen or halogen or a trihalomethyl, lower alkyl, lower alkoxy, nitro, hydroxyl, aralkyloxy or an 1-(2-propenyl-4-piperazinyl) group;

1,4-Disubstituted piperazines having dopaminergic activity

The invention relates to novel benzhydryl-piperazine derivatives of the general formula (I) and the acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are the same or different and stand for hydrogen or halogen, or a trihalomethyl, C.sub.1-4 alkyl or C.sub.1-4 alkoxy group;

Benzhydrylpiperazines pharmaceutical compositions thereof and method of

The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1 and R.sub.2 are the same or different and stand for hydrogen or halogen or a lower alkyl, trihalomethyl or lower alkoxy group. The compounds of the general formula (I) are therapeutically useful for the treatment of diseases arising from a hypofunction of the dopaminergic system.

1,4-disubstituted piperazines, pharmaceutical compositions thereof and

The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein X stands for a halogen;

2-Halogenated-8- and 1,8-substituted ergolenes

The invention relates to a new process for preparing novel racemic and optically active 9- or 11-nitroapovincaminic acid derivatives of the general formula (I) ##STR1## wherein R stands for a --CO--X group, wherein X means a halogen atom; or

Nintrovincaminic acid derivatives having pharmaceutical utility

The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), ##STR2## wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong .alpha.-adrenerg blocking and calcium-antagonistic action.

2-chloronicergoline having antihypoxic activity

The invention relates to pharmaceutical compositions with a neuroleptic action as well as to a process for preparing these compositions. The active ingredients of the compositions of the invention are 2-halo-6-methyl-9-ergolene derivatives of the formula (I), ##STR1## wherein X represents a chlorine, bromine or iodine atom as well as their acid addition salts. The compositions of the invention contain an effective dose of compound of the general formula (I) or an acid addition salt thereof.

Pharmaceutical compositions with a neuroleptic action and process for

The invention relates to new racemic and optically active apovincaminic acid derivatives of the general formula (I) ##STR1## wherein A is hydroxyl, halogen or a group --O--(CH.sub.2).sub.n --OR.sup.1 or --OMe, in which

Novel apovincaminic acid derivatives

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Budapest, Hungary

Dora Groo