Gador S.a.

Gador Sociedad Anonima

Conicet -consejo Nac. De Investigaciones Científicas Y Técnicas

Dora Graciela Tombari

Rafael Alberto Labriola

Adriana Vechhioli

Adriana Vecchioli

Constanza Pia Mangone

Maria Beatriz Garcia

Eduardo Miguel Rustoy

Gerardo Burton

A new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.

Crystalline form of the zoledronic acid, a process to obtain it and the pharmaceutical composition comprising it

A method to obtain a new crystalline form of the Zoledronic acid, characterized by its X-rays diffractogram as well as by its spatial atomic distribution in the red crystalline and its curves of thermal analysis. There is also included a method to obtain this crystalline form, which includes the synthesis of the corresponding acid and the pharmaceutical composition this crystalline form comprises.

The solid state chemistry of 17&#x3b2;-N-[2,5-bis(trifluoromethyl)phenyl]carbamoyl-4-aza-5-&#x3b1;-androst-1-en-3-one of which the international nonproprietary name is Dutasteride (the active ingredient in products marketed as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost) and its process for preparing. The synthetic process comprises formation of the mixed anhydride, its subsequent reaction with 2,5-bis(trifluoromethyl)phenylamine in the presence of an appropriate Lewis catalyst and its isolation, purification and crystallization from acetonitrile/water.

Solid and crystalline dutasteride and processes for preparation thereof

The present invention is related to an oxime of the 13&#x3b2;-ethyl-17&#x3b1;-hydroxi-18,19-dinorpregn-4-en-20-in-3-o (norelgestromin) of Formula I with a relation of isomers E/Z between 1.3 and 1.6 and the method of producing the oxime.

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Buenos Aires, Argentina

Dora Graciela Tombari