Southern Research Institute

Pinotbio, Inc.

Doo Young Jung

Jin Soo Lee

Mark J Suto

Hyunyong Cho

Rebecca Boohaker

The present invention relates to pharmaceutical compositions for treating blood cancer, which includes 4'-thio-5-aza-2′-deoxycytidine (Aza-T-dCyd), and methods of treating blood cancer using a composition for oral administration that includes Aza-T-dCyd. The present invention provides a significant blood cancer therapeutic effect without having toxicity in a blood cancer mouse model or a human even with the Aza-T-dCyd dose conventionally known to have toxicity. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Composition for treating blood cancer using 4'-thio-5-Aza-2′-deoxycytidine and uses thereof

The present disclosure provides crystalline polymorphs of 5-aza-4'-thio-2&#x2032;-deoxycytidine. The crystalline polymorphs may be formulated in a pharmaceutical composition, optionally in combination with an additional chemotherapeutic agent. The crystalline polymorphs are useful to treat various diseases including blood cancers, such as myelodysplastic syndrome and leukemia. A process for preparing the crystalline polymorphs of 5-aza-4&#x2032;-thio-2&#x2032;-deoxycytidine is also disclosed. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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Daejeon, South Korea

Doo Young Jung