Legochem Biosciences, Inc.

Intocell, Inc.

Doo Hwan Jung

Sun Young Kim

Sung Ho Woo

Hyang Sook Lee

Tae Kyo Park

Jong Un Cho

Yong Zu Kim

Ho Young Song

Jeiwook Chae

Yeong Soo Oh

Chul-Woong Chung

Yun Hee Park

Jeong Hee Ryu

Kyu Man Oh

Ji Young Min

Jeon Yang

Sang Kwang Lee

Beom Seok Seo

Su Ho Park

Ji Yeon Lim

Jae Ho Lee

Dong Hoon Seo

The present invention relates to a compound bearing a self-immolative linker having &#x3b2;-galactoside-introduced thereto. In a compound bearing a &#x3b2;-galactoside-introduced self-immolative linker according to the present invention, particularly, the self-immolative linker may form a glycosidic bond with a protein (e.g., an oligopeptide, polypeptide, an antibody, etc.) or ligand which has specific affinity for a desired target or with an active agent (e.g., a drug, a toxin, a ligand, a detection probe, etc.), which has a specific function or activity so as to allow the selective release of the active agent within a target cell.

Compound bearing beta-galactoside-introduced self-immolative linker

Provided herein are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

Compounds comprising self-immolative group

Provided are compounds comprising a self-immolative group, and the compounds comprising a self-immolative group according to the present invention may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

Provided are methods of use of compounds comprising a self-immolative group, which compounds may include a protein (for example, an oligopeptide, a polypeptide, an antibody, or the like) having substrate-specificity for a target and an active agent (for example, a drug, a toxin, a ligand, a detection probe, or the like) having a specific function or activity.

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Daejeon, South Korea

Doo Hwan Jung