Other

Kaer Biotherapeutics Corporation

Cytoptics Corporation

Biotechplex Corporation

Yeates, Donovan B.

Donovan B Yeates

Xin Heng

Guanglin Li

Lid B Wong

Peter J Hesketh

Hua Mao

Kim SangKyung

Tarun Chandra

Mahandas A Kizhakayil

Jinghai Yi

Peter Hesketh

Sangkyung Kim

An aerosol generating system for generating a respirable dry powder aerosol from a liquid solution or liquid suspension, having: a liquid aerosol generating nozzle having a nozzle input end designed to receive the liquid solution or liquid suspension, and having a nozzle heliox supply designed to receive nozzle heliox, the liquid aerosol generating nozzle further having a nozzle output end for outputting a liquid aerosol suspended in the nozzle heliox; and a cylindrical evaporation chamber having a cylindrical evaporation chamber input end that is connected to the nozzle output end and connected to a dilution heliox supply for receiving both the liquid aerosol suspended in the nozzle heliox and for receiving the dilution heliox, and the cylindrical evaporation chamber having a cylindrical evaporation chamber output end outputting a first intermediate dry powder aerosol at a first intermediate dry powder aerosol volume flow of a specific concentration.

Apparatus and method for generating fine particle aerosols with heliox

A system and a method for generating a respirable dry powder aerosol () from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (). A liquid aerosol generating nozzle () generates from the liquid solution or liquid suspension a liquid aerosol () that is diluted by dilution gas () and dried in a cylindrical evaporation chamber () to generate a dry powder aerosol () that is subsequently concentrated. The system and method may include heliox as a gas, specifically dilution gas (), for enhancing both the drying process in the cylindrical evaporation chamber () and for enhancing the concentration efficiency, but also as a nozzle gas () for enhancing generating the liquid aerosol () from the liquid solution or liquid suspension.

Apparatus and method for generating particle aerosols with heliox

A nozzle and a method of generating an inhalable aerosol from a liquid solution or liquid suspension and a gas by operating the nozzle. A column-like aerosol plume is generated having fluid particles within a particle free sheath of gas, the aerosol plume being generated from a compressed gas interacting within the aerosolizing space with a fluid ejected along the central axis, and generates a Venturi effect entraining gas that flows over the convex outer nozzle surface that together with the particle free sheath keeps the circumferential edge and the outer nozzle surface free of particle deposition. An aerosol exit orifice diameter is at least 1.3 times larger than the fluid exit orifice diameter; and a converging annular pressurized gas channel extending at an acute gas flow angle of 10-30&#xb0; with respect to a central axis.

Aerosolizing nozzle and method of operating such aerosolizing nozzle

A system and a method for generating a respirable dry powder aerosol () from a liquid solution or liquid suspension at a respirable dry powder aerosol volume flow (). A liquid aerosol generating nozzle () generates from the liquid solution or liquid suspension a liquid aerosol () that is diluted by dilution gas () and dried in a cylindrical evaporation chamber () to generate a dry powder aerosol () that is subsequently concentrated by a cylindrical single linear slit aerosol concentrator (). The system and method may include heliox as a gas, specifically dilution gas (), for enhancing both the drying process in the cylindrical evaporation chamber () and for enhancing the concentration efficiency, but also as a nozzle gas () for enhancing generating the liquid aerosol () from the liquid solution or liquid suspension.

Apparatus and method for generating and concentrating fine particle aerosols

Two-stage apparatus and method for generating and concentrating fine particle aerosols

A nozzle and a method of generating an aerosol from a fluid and a gas by operating the nozzle. The nozzle has an aerosol exit orifice of a larger diameter and a fluid exit orifice of a smaller diameter aligned on a common central axis. A pressurized gas from a pressurized gas exit in close proximity to the fluid exit orifice intersects a fluid jet exiting from the fluid exit orifice at that acute angle and in a distance from the aerosol exit orifice. The method includes aerosolizing a fluid with a viscosity exceeding 4 cSt delivering an inhalable medication at a rate of more than 1 ml/minute, thereby delivering a medication at a mass flow rate of at least 30 mg/minute in form of the fluid particles having a mass median aerodynamic diameter (MMAD) of 6 &#x3bc;m or less.

A method of aerosolizing a liquid by generating an aerosol from a liquid fluid and a gas with a nozzle having a cone-shaped gas exit channel, the method including the method steps of: ejecting a nozzle gas jet through an orifice at the cone apex; generating a zone of low pressure by the ejected nozzle gas jet, the zone of low pressure augmenting a flow of liquid fluid in a direction from a nozzle cone base towards the orifice at the cone apex; and aerosolizing the liquid fluid at the aerosolizing perimeter where the liquid fluid that flows towards the orifice is sheared by the nozzle gas jet.

Method of aerosolizing a liquid

A nozzle for generating an aerosol from a fluid and a gas is described. The nozzle comprises at least one wettable cone-shaped gas exit channel that widens in a direction of gas flow from a cone apex to a cone base of the wettable cone-shaped gas exit channel and is connected at the cone apex to a nozzle gas supply channel. The nozzle further comprises at least one annular fluid exit port at the circumference of the cone base that is connected to a nozzle fluid supply channel. Further, a nozzle holder is described. The nozzle holder comprises a cylindrical crown comprises a plurality of circumferentially spaced grooves that are connected to the ring-shaped fluid exit port.

Nozzle and nozzle holder for an aerosol generator

A flow conditioner for generating and diluting an aerosol with a first inlet adapted to receive a first volume flow of pressurized gas. A second inlet is adapted to receive a second dilution gas volume flow and a third inlet adapted to receive a fluid to be converted into an aerosol. A nozzle is connected to the first and third inlet and has a nozzle orifice for outputting a first aerosol. A first dilution gas flow partitioner has a first set of openings penetrating the first dilution gas flow partitioner and a second dilution gas flow partitioner that is spaced apart from the first dilution gas partitioner and has a second set of openings penetrating the second dilution gas flow partitioner. The nozzle orifice is positioned in the proximity of the second dilution gas flow partitioner.

Flow conditioner for a compact, low flow resistance aerosol generator

A method is described comprising: providing a first heated volume flow of pressurized gas, a second volume flow of pre-heated dilution gas, and a third volume flow of fluid. A concentrated first aerosol is generated by exhausting at least a part of the first volume flow of pressurized gas and the third volume flow of fluid through a nozzle. A fourth volume flow of gas of opposite direction to the concentrated first aerosol is generated such that the concentrated first aerosol is arrested. Evaporation of the aerosol solvent is augmented with infrared radiation. The arrested first aerosol is then mixed with the second volume flow of dilution gas for generating a second aerosol that has been diluted. This aerosol is then concentrated with a virtual impactor.

Method of operating a compact, low flow resistance aerosol generator

A concentrator for increasing the particle concentration in an aerosol flow is described. The concentrator comprises a sculptured acceleration plate with a number of slit-shaped and radially extending acceleration channels and a sculptured deceleration plate with a number of slit-shaped and radially extending deceleration plate channels. Acceleration channel exit openings are spaced from a base surface on an exit side of the acceleration plate and sculptured deceleration channel entry openings are spaced from a base surface on an entry side of the deceleration plate so that a relatively large gap is provided between the acceleration plate base surface and the deceleration plate base surface allowing a waste volume flow to be exhausted through this relatively large gap at low flow resistance. The plurality of openings comprises openings of at least two different lengths.

Concentrator for increasing the particle concentration in an aerosol flow

A system and method that can simultaneously acquire electrocardiogram or pulse rate data (), dynamically perform time-frequency () and chaotic analysis () in real-time, visually display the results in a convenient graphical format () and store the results in a computer file format ().

Instantaneous autonomic nervous function and cardiac predictability based on heart and pulse rate variability analysis

A method and system is disclosed which is capable of delivering at a high dose rate, respirable solid aerosols derived from aqueous- or nonaqueous-based solutions containing the desired therapeutic agent(s). The method and system comprises the integration of an aerosol generator, an aerosol evaporator, an aerosol concentrator, and an aerosol flow regulator. The aerosol generator generates 10-30 &#x3bc;m droplets, with a narrow size distribution. The aerosol jet is arrested by a coaxial counter-flow heated air jet, and evaporated rapidly by annular swirling heated air. Most of the air, together with the unwanted solvent vapor, is removed from the aerosol stream during the process of aerosol concentration. The output aerosol carries the dry particles to be inhaled by the patient. The respiratory-governed control of aerosol fluid generation system delivers fluid containing the test agent of interest (drug or toxin) to the aerosol generator throughout inhalation.

Aerosol processing and inhalation method and system for high dose rate aerosol drug delivery

A system for monitoring low dynamic pressures in confined spaces, such system comprising a catheter, a multilayered corrugated membrane of diameter less than 2 mm with a reflective inner layer mounted within said catheter; a set of optical fibers comprising one or more illuminating fibers and two or more detecting fibers which are contained within said catheter and whose ends are set at differing distances from the membrane; an illuminating system coupled to said illuminating fibers; and a detection system coupled to said illuminating fibers.

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Escondido, CA, United States of America

Donovan B Yeates