Nektar Therapeutics

Evotec Ag

Novabay Pharmaceuticals, Inc.

Donogh John Roger O'Mahony

Neel Kumar Anand

Bo-Liang Deng

Natalia Aurrecoechea

YongQi Mu

Zhongxu Ren

Eric Douglas Turtle

Charles Francavilla

Timothy Shiau

Eddy Low

Antoni Kozlowski

Jennifer A Riggs-Sauthier

Michael G Kelly

Xiaoming Shen

Lin Cheng

Matthew Duncton

Timothy A Riley

Rakesh K Jain

John Kincaid

Pankaj Sharma

Xuyuan Gu

Zhi-Liang Wei

Matthew Cox

Yuan Song

Xuejun Yuan

Maria De Los Angeles Estiarte-Martinez

Vijay Kumar Khatri

Michael Lixin Shen

Aleksandrs Odinecs

Wen Zhang

Zhan Wang

Haiying Cai

Carl J Kaub

Andrew Antony Calabrese

Ramin Najafi

Matthew Alexander James Duncton

Tadashi Kawashima

Satoshi Nagayama

Yuji Shishido

Hirotaka Tanaka

Erik Krogh-Jespersen

Anthony James Brockway

Mathew Cox

The instant disclosure provides novel adenosine receptor antagonist compounds, compositions, methods of making and methods of using. In a further aspect, a method of treating a subject in need thereof, comprising administering a therapeutically effective amount of any one or more of the compounds described herein. In some embodiments, the subject has cancer and the method is a method of treating cancer.

Adenosine 2 receptor antagonists

The instant disclosure relates to (among other things) compounds that are derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine. The compounds provided possess unique effects and differences over other phenyltriazines known in the art.

Derivatives of 6-(2,3-dichlorophenyl)-1,2,4-triazin-5-amine

The present invention relates to compounds and their use as ligands for mu opioid receptors. Also included are methods for preparing the compounds and pharmaceutical compositions containing the compounds. In one or more embodiments of the invention, a compound according to Formula I is provided: and pharmaceutically acceptable salts thereof, wherein R-Rare as described herein. 

Morphinan derivatives for the treatment of neuropathic pain

The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.

Substituted N,N-dihaloamines as antimicrobials

The invention monitors the neutralization process involving hydrogen peroxide solution and a hydrogen peroxide neutralization catalyst and compares measured values with theoretical values. The system monitors the chemical reaction and notifies the user of the neutralization status. In an exemplary embodiment, the initial hydrogen peroxide solution concentration is neutralized with a palladium catalyst after a period of time. A microcontroller analyzes the measurements and displays the neutralization process results using colored LED lights and/or text or images on a LCD display. In one embodiment, an apparatus adapted for use with a cleaning solution used to clean a medical device may include a trigger, a processing device in communication with the trigger, and a display device. The processing device provides a trigger count and the display device communicates with the processing device and displays a message based on the count.

Contact lens cleaning system with monitor

This application describes compounds useful as anti-microbial agents, including as antibacterial, disinfectant, antifungal, germicidal or antiviral agents.

Antimicrobial haloalkyl heterocycle compounds

Fused heterocyclic compounds are provided according to formula 1a or 1b:  where R, R, and Rare as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof

Compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, traumatic injury, and others.

Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same

Fused heterocyclic compounds are provided according to formula 1: where R, R, R, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

2-cyanophenyl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine compounds, compositions and uses thereof

Growing community of inventors

San Mateo, CA, United States of America

Donogh John Roger O'Mahony