Warner-Lambert Company

Donna Reynolds Cody

Mel C Schroeder

Haile Tecle

Stephen Douglas Barrett

Alexander James Bridges

Annette Marian Doherty

Alan Robert Saltiel

David Thomas Dudley

Bruce D Roth

John S Kiely

John C Hodges

Walter H Moos

Michael R Pavia

Sheila H DeWitt

Charles J Stankovic

Phenylamino benzoic acid, benzamides, and benzyl alcohol derivatives of the formula

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives

2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as MEK inhibitors

The present invention provides a method for treating or preventing septic shock. Specifically, the present invention provides a method of treating or preventing septic shock by administering to a patient a MEK inhibitor.

Method of treating or preventing septic shock by administering a MEK inhibitor

A method for the multiple, simultaneous synthesis of compounds comprising the steps of: 1) providing an apparatus comprising a plurality of reaction tubes having filter members on their lower ends, a reservoir member for receiving the filter member, a holder member having a plurality of apertures for supporting the reaction tubes, and a manifold member adjacent to the holder member and enclosing the upper ends of the reaction tubes; 2) charging the apparatus with reactants required for synthesis; 3) synthesizing the compounds in solution; or optionally 4) cleaving the compounds from a solid support within the apparatus.

Apparatus and method for multiple simultaneous synthesis

An apparatus and method which provides a suitable location for multiple, simultaneous synthesis of compounds. The apparatus consists of: a reservoir block having a plurality of wells; a plurality of reaction tubes, usually gas dispersion tubes, having filters on their lower ends; a holder block, having a plurality of apertures; and a manifold, which may have ports to allow introduction/maintenance of a controlled environment. The manifold top wall has apertures and a detachable plate with identical apertures. The apparatus is constructed from materials which will accommodate heating, cooling, agitation, or corrosive reagents. Gaskets are placed between the components. Rods or clamps are provided for fastening the components together. Apparatus operation involves placing the filters on the lower ends of the reaction tubes in the reservoir block wells, and the upper ends passing through the holder block apertures and into the manifold. The apparatus provides in excess of 1 mg of each product with structural knowledge and control over each compound. Using the apparatus a series of building blocks are covalently attached to a solid support. These building blocks are then modified by covalently adding additional different building blocks or chemically modifying some existing functionality until the penultimate structure is achieved. This is then cleaved from the solid support by another chemical reaction into the solution within the well yielding an array of newly synthesized individual compounds, which after postreaction modification, if necessary, are suitable for testing for activity.

Apparatus for multiple simultaneous synthesis

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Saline, MI, United States of America

Donna Reynolds Cody