Sommetrics, Inc.

Metallopharm, LLC

5i Sciences

Donna Palmer

John Richard Nelson

Jerome K Aarestad

Richard Rose

Paulo Rangel

James A Cowan

Ada S Cowan

John Nelson

A device and a method for creating and/or maintaining an obstruction free upper respiratory passages. The device is configured to fit under the chin of a subject adjacent to the subject's neck at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The device is capable of exerting negative pressure on the surface of a subject's neck, displacing the soft tissue forward and enlarging the airway.

Device and method for opening an airway

A device and a method for creating and/or maintaining an obstruction free upper airway. The device is configured to fit under the chin of a subject adjacent to the subject's neck at an external location corresponding approximately with the subject's internal soft tissue associated with the neck's anterior triangle. The device is capable of exerting negative pressure on the surface of a subject's neck, displacing the soft tissue forward and enlarging the airway.

It is an object of the present invention to provide improved pharmacological properties to molecules which bind to a target with low affinity (hereinafter referred to as a 'ligand moiety') through linkage of such molecules to a metal binding moiety, thereby generating a combination molecule commonly referred to as a 'metallodrug' or &#x201c;metallotherapeutic.&#x201d; The metal binding domain of metallodrugs typically catalyzes oxido-reductase chemistry or acts as a Lewis-Acid catalyst, resulting in modification of proteins and nucleic acids that are in close proximity due to binding of the ligand moiety to its target.

Metallodrugs having improved pharmacological properties, and methods of manufacture and use thereof

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San Diego, CA, United States of America

Donna Palmer