US Government As Represented by the Secretary of the Army

University of Massachusetts

Aveo Pharmaceuticals, Inc.

Donna McIntosh

Jayant Kumar

Ferdinando F Bruno

Lynne Ann Samuelson

Jeno Gyuris

Ramaswamy Nagarajan

Kristan Meetze

Sylvie Vincent

Steve Bottega

Bin Feng

Steven Tyler

Susan J Braunhut

Richard Nicoletti

Subhalakshmi Nagarajan

Klaudia Foley

A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.

Predicting tumor response to anti-ERBB3 antibodies

A method for synthesizing a biocompatible, water-soluble oligo/polyflavanoid, includes polymerizing an optionally substituted flavanoid with a polymerization agent in the presence of a biocompatible polymerization solubilizer, thereby producing the biocompatible, soluble oligo/polyflavanoid. Also included is a biocompatible, soluble, oligo/polyflavanoid or a pharmaceutically acceptable salt, solvate, or complex thereof. Also included are methods of treating a subject for cancer, cardiac damage, viral infection, and obesity.

Synthesis of oligo/poly(catechins) and methods of use

Growing community of inventors

Chelmsford, MA, United States of America

Donna McIntosh