Genentech, Inc.

Pfizer Corporation

Rinat Neuroscience Corporation

Cellectis

Allogene Therapeutics, Inc.

Donna Marie Stone

Arnon Rosenthal

Frederic J De Sauvage

Austin L Gurney

William I Wood

Jaume Pons

Mei Li

Maximilien Murone

Vishwas Madhav Paralkar

Arvind Rajpal

Laurent Poirot

Barbra Johnson Sasu

Alexandre Juillerat

John Lippincott

Thomas Charles Pertel

Ping Wei

Shobha Chowdary Potluri

Kang Li

Qinghai Peng

Zdenek Hostomsky

Frederick J De Sauvage

The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TXYXXX, wherein Xis an amino acid Xis an amino acid Xis an amino acid and Xis V or I.

Inhibitory chimeric antigen receptors

This invention is directed toward monoclonal antibodies that bind specifically to Notch1. In one embodiment, the antibodies binds to at least a first epitope and a second epitope, wherein the first epitope resides with the LinA domain of the Notch1 negative regulatory region (NRR), and the second epitope resides within the HD-C domain of the Notch1 NRR.

Anti Notch-1 antibodies

The present invention provides antibodies and fragments thereof that bind to Dkk-1 and, in particular, to humanized antibodies and fragments thereof that bind to Dkk-1 and, even more particularly to fully humanized antibodies and immunologically functional fragments that bind to Dkk-1. Also provided are antibodies and fragments thereof which compete with the binding of an anti-mouse Dkk-1 monoclonal antibody for binding to Dkk-1cells. Also provided are nucleic acids encoding anti-Dkk-1 antibodies or fragments thereof, as well as expression vectors and host cells incorporating these nucleic acids for the recombinant expression of anti-Dkk-1 antibodies and fragments thereof. Also provided are methods of preparing the antibodies and fragments thereof of the invention. Also provided are bone anabolic agents. Pharmaceutical compositions comprising the antibodies or fragments thereof of the invention are also provided. Further provided are methods of treating diseases, conditions and disorders, such as bone disorders, which result in a loss of bone. Methods of treating or preventing a loss of bone mass, methods of inducing increased bone mass, and methods of inducing Wnt activity are also provided.

Antibodies specific for DKK-1 and their uses

The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of thefused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Assay methods for suppressor of fused modulation of hedgehog signaling

The present invention is directed to novel polypeptides having homology to a polypeptide suppressor of themelanogaster fused protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Nucleic acid encoding human suppressor of fused

Novel vertebrate homologues of Smoothened, including human and rat Smoothened, are provided. Compositions including vertebrate Smoothened chimeras, nucleic acid encoding vertebrate Smoothened, and antibodies to vertebrate Smoothened, are also provided.

Vertebrate smoothened proteins

Vertebrate smoothened antibodies

Antibodies to vertebrate smoothened proteins

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Brisbane, CA, United States of America

Donna Marie Stone