Multi-magnetics Inc.

Donna E Goldhawk

Frank S Prato

Alex W Thomas

R Terry Thompson

Terry R Thompson

D James Koropatnick

Savita Dhanvantari

Neil Gelman

David Hill

Rene Figueredo

Cheryl R McCreary

Rebecca McGirr

Cheryl R Mccreary

The invention provides an improved modified magnetosome that contains more iron therein with the combination of the expressed genes. This is achieved by co-expression of (a) one or more bacterial magnetotactic genes to amplify iron uptake, compartmentalization and biomineralization in cells, with (b) one or more mammalian iron handling proteins that together augment(s) and/or regulate the cells iron pool. As a result, mammalian cells or bacterial cells that are transfected or transformed, respectively, can be more effectively tracked using various imaging technologies.

Co-expression of magnetotactic bacterial genes and genes encoding iron handling proteins in cells

The invention is the production of magnetosome-like structures in cells. The invention provides in vitro and in vivo diagnostic and therapeutic methods using eukaryotic cells expressing magnetosome-like structures that act as contrast agents.

Magnetosome gene expression in eukaryotic cells

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London, Canada

Donna E Goldhawk