Euro-Celtique S.a.

Donna Donigi-Gale

Mark Chasin

Paul D Goldenheim

Richard S Sackler

Peter Lacouture

Kevin Burton

Amol Ketkar

Sustained release local anesthetic formulations are administered intra articularly and/or into body spaces/cavities. The formulation is preferably a plurality of injectable microparticles including a local anesthetic and an effective amount of a biocompatible, biodegradable, sustained release material prolonging the release of the local anesthetic and optionally and a pharmaceutically acceptable, i.e., non-toxic, augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable without the augmenting agent.

Prolonged anesthesia in joints and body spaces

A formulation for inducing sustained regional local anesthesia in a patient comprising a substrate comprising a local anesthetic and an effective amount of a biocompatible, biodegradable, controlled release material prolonging the release of the local anesthetic from the substrate to obtain a reversible local anesthesia when implanted or injected in a patient, and a non-toxic augmenting agent effective to prolong the duration of the local anesthesia for a time period longer than that obtainable from the substrate without the augmenting agent. In preferred embodiments, the controlled release material is a low molecular weight, acid-terminated polymer. A further aspect of the invention is directed to such formulations which release the local anesthetic in two phases, the first a rapid &ldquo;bolus&rdquo; to initiate anesthesia and a second, slower release to maintain anesthesia.

Formulations and methods for providing prolonged local anesthesia

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Richfield, CT, United States of America

Donna Donigi-Gale