University of Florida Research Foundation Inc

Xhale, Inc.

Donn Dennis

Richard Joel Melker

Nikolaus Gravenstein

Dinesh Ochhavlal Shah

Timothy E Morey

Christopher D Batich

Richard Earl Partch

Charles R Martin

Manoj Varshney

Mark J Rice

Matthew M Booth

Jon Dale Stewart

Jeremy Melker

Susan L Baumgartner

Douglas Crumb

Robert Hurley

Jerome H Modell

Ronald L Hayes

Mark Tanner

Mark Gold

Chris Batich

David G Bjoraker

Richard J Rogers

Poonam Kaul

Scott Howard Wakefield

William David Chura

Tom Bigger

Hank Wohltjen

John Frederick Horn, Jr

Marks Tanner

Scott Wasdo

Ronald E Youngblood

Ka-Wang Kevin Wang

Anatoly E Martynyuk

Alexander V Glushakov

Richard Allen

Colin Sumners

A Self Monitoring And Reporting Therapeutics, SMART&#xae; composition, method apparatus and system are provided which flexibly provide options, by combining different embodiments of the device with different embodiments of the composition, the ability to conduct definitive medication adherence monitoring over the short term (Acute Medication Adherence Monitoring, immediately up to an hour or so after taking a medication), intermediate term (Intermediate Medication Adherence Monitoring, IMAM, an hour or so to a day or so after taking a medication), and longer term (Chronic Medication Adherence Monitoring, CMAM, a day to several days after taking a medication).

Medication adherence monitoring device

Provided according to embodiments of the invention pharmaceutical capsules that include a capsule body and a capsule cap, wherein the capsule cap envelops an open end of the capsule body to form a capsule core; and an adherence sheath that envelops a portion of the capsule core. Related capsules and methods of making such capsules are also provided herein.

Pharmaceutical capsules for medication adherence monitoring and methods of forming the same

A monitoring and control system, apparatus and method for safe administration, reduction or cessation of administration of at least on medication, fluid or both, which includes at least one Central Source Site (CSS) Photoplethysmography (PPG) sensor coupled to means for control of delivery of the at least one medication, fluid or both.

Central site photoplethysmography, medication administration, and safety

A pharmacodynamic (PD), pharmacokinetic (PK), or both and PK guided infusion device, system and method optimizes the safety and efficacy of various forms of treatment or therapy (e.g., drug and/or fluid) in a variety of health-care and other settings.

Intelligent drug and/or fluid delivery system to optimizing medical treatment or therapy using pharmacodynamic and/or pharamacokinetic data

Miniature portable gas chromatograph

Systems and methods are provided for monitoring use of handwashing agents to determine compliance with hand hygiene guidelines. A handwashing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's handwashing technique. After the handwashing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the handwashing agent and hand hygiene compliance.

Handwashing compliance detection system

Systems and methods are provided for monitoring use of hand washing agents to determine compliance with hand hygiene guidelines. A hand washing agent is provided with a detectable, volatile compound, such as odors, which is then rubbed onto a subject's hands using the subject's hand washing technique. After the hand washing event, the subject's hand is then exposed to an detector (such as a badge), which includes a sensor capable of detecting the volatile compound, and an indicator that communicates detection of the volatile compound, indicating use of the hand washing agent and hand hygiene compliance.

Hand washing compliance detection system

The present invention provides systems and methods for analyzing glucose present in exhaled breath condensate (EBC). In certain embodiments of the invention, electrochemical- or coulometric-based sensing technologies are used to analyze EBC for the presence and/or concentration of glucose.

Condensate glucose analyzer

A method of removing a toxic compound comprising contacting the toxic compound with a particle having two regions, the first region containing a detoxifying enzyme and the second region containing a material selected to partition the toxic compound into the second region. The particle may be a nanoparticle.

Detoxification and decontamination using nanotechnology therapy

The subject invention provides microemulsions having, as one component thereof, electron-deficient aromatic rings, e.g.. di(trifluoromethyi) benzene, for efficient separation and/or isolation of target molecules, e.g., bupivacaine.

Microemulsions for selective molecular separation

The invention relates to the nanotubes of various sizes and composed of a wide variety of materials, or combination of materials. The invention also describes the use of such nanotubes for the delivery of various payloads and, in particular, for the in vivo delivery of bioactive substances.

Nanoparticle delivery system

Systems and methods for the ex vivo diagnostic analysis of samples of bodily fluids, including exhaled breath and blood. The present invention uses nanostructure-based assemblies in combination with sensor technology to provide an efficient and accurate means for identifying the presence of a target analyte/biomarker in a sample of bodily fluid. In a preferred embodiment, the nanostructure-based assemblies of the present invention include detecting means such as RNA oligonucleotide chains or 'apparatus' and releasable surrogate markers such as DMSO.

Application of nanotechnology and sensor technologies for ex-vivo diagnostics

A particle with two regions, the first region contains a detoxifying enzyme and a second region that partitions toxic compounds. The particle may be a nanoparticle.

A method for detecting compounds of interest in bodily fluids, including exhaled breath and blood. The present invention uses biosensors that mimic naturally occurring cellular mechanisms, including RNA oligonucleotide chains or 'aptamers,' in combination with molecular beacons or nanotechnology to provide an effective and efficient method for diagnosing a condition and/or disease within a patient. The subject invention also provides a method for screening those analytes/biomarkers likely to be present in exhaled breath.

Application of biosensors for diagnosis and treatment of disease

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Gainesville, FL, United States of America

Donn Dennis