Harvard College

Samsung Electronics Co., Ltd.

Schlumberger Technology Corporation

Donhee Ham

Hongkun Park

Jeffrey T Abbott

Wenxuan Wu

Hyeonjin Shin

Tianyang Ye

Houk Jang

Haeryong Kim

Henry Julian Hinton

Minhyun Lee

William Franklin Andress

Yong Liu

Han Sae Jung

Yeonchoo Cho

Nan Sun

David Ricketts

Xiaofeng Li

Dovran Amanov

Chengye Liu

Renjing Xu

Jinseong Heo

Seongjun Park

Yi-Qiao Song

Changhyun Kim

Philip Kim

Jeffrey Paulsen

Marsela Jorgolli

Dongwan Ha

Ling Qin

Keith Krenek

Disclosed herein are an apparatus for electrically assessing and/or manipulating cells. One aspect is directed to electrically mapping cells on the surface of the semiconductor substrate via cross-electrode impedance measurements. Further according to some aspects, the electrode array allows for spatially addressable electrical stimulation and/or recording of electrical signals in real-time using the CMOS circuitry. Some of these aspects are directed to using an electrode array to perform cell patterning through electrochemical gas generation, and extracellular electrochemical mapping.

Systems and methods for patterning and spatial electrochemical mapping of cells

Disclosed herein are semiconductor devices to provide a CMOS-compatible, wafer-scale, multi-well platform that can be used for biomedical or other applications, and methods to operate the same. In some embodiments, circuitry is provided underneath a multiple-well array to electrically interface with electrodes in the wells. To interface with electrodes in a large array, circuitry may be fabricated on a single silicon (Si) wafer having a dimension that is at least the same or larger than that of the multiple-well array. According to one aspect of the present disclosure, standard CMOS fabrication process such as those known to be used in a standard semiconductor foundry may be used without expensive customization for complex fabrication procedures. This may help the production cost to be lowered in some cases.

Complementary metal-oxide-semiconductor (CMOS) multi-well apparatus for electrical cell assessment

A nonvolatile memory device includes a resistance switching layer, a gate on the resistance switching layer, a gate oxide layer between the resistance switching layer and the gate, and a source and a drain, spaced apart from each other, on the resistance switching layer. A resistance value of the resistance switching layer is changed based on an illumination of light irradiated onto the resistance switching layer and is maintained as a changed resistance value.

Nonvolatile memory device and operating method of the same

Methods and systems for monitoring the activity of electrogenic networks are described. One representative system includes an array of electrode coupled to an analyzer having a stimulator and a receiver. The electrode is placed in contact with an electrogenic cell. The electrodes can be shaped as nanowires, tubes, cavities and/or cones. The analyzer may be configured to operate in a voltage stimulation mode, in which the cells are stimulated via voltages and monitored via current, or in a current stimulation mode, in which the cells are stimulated via currents and monitored via voltages. The analyzers may be arranged as single-stage amplifiers, and may include a feedback loop shared between the stimulation signal path and the sensing signal path. The feedback loop may be arranged to provide overlapping stimulation and sensing of the electrogenic network's cells.

Electronic circuits for analyzing electrogenic cells and related methods

Disclosed is a neural computer including an image sensor capable of controlling a photocurrent. The neural computer according to an embodiment includes a preprocessor configured to receive an image and generate a feature map for the received image; a flattening unit configured to transform the feature map generated by the preprocessor into tabular data to provide data output; and an image classifier configured to classify images received through the preprocessor by using the data output by the flattening unit as an input value. The preprocessor includes an optical signal processor configured to receive the image and generate the feature map.

Neural computer including image sensor capable of controlling photocurrent

Provided are memristors and neuromorphic devices including the memristors. A memristor includes a lower electrode and an upper electrode that are apart from each other and first and second two-dimensional material layers that are arranged between the lower electrode and the upper electrode and stacked without a chemical bond therebetween.

Memristor and neuromorphic device comprising the same

The present invention generally relates to nanowires. In one aspect, the present invention is generally directed to systems and methods of individually addressing nanowires on a surface, e.g., that are substantially upstanding or vertically-oriented with respect to the surface. In some cases, one or more nanowires may be individually addressed using various integrated circuit ('IC') technologies, such as CMOS. For example, the nanowires may form an array on top of an active CMOs integrated circuit.

Integrated circuits for neurotechnology and other applications

Methods and systems for stimulating and monitoring electrogenic cells are described. Some systems for stimulating electrogenic cells are based on the injection of electric currents into the cells via electrodes connected to the cells. Such stimulators may comprise an impedance element having an input terminal and an output terminal coupled to an electrode, and a voltage follower coupled between the input terminal and the output terminal of the impedance element, the voltage follower being configured to maintain a substantially constant voltage between the input terminal and the output terminal of the impedance element. The impedance element may comprise one or more switched capacitors at least in some embodiments. In some embodiments, the voltage follower may be implemented using a source follower.

Current-based stimulators for electrogenic cells and related methods

Apparatuses for cell mapping via impedance measurements and methods to operate the same

A light-emitting device includes a substrate including a photonic cavity and configured to function as a gate, an active layer including a two-dimensional material, a first conductive contact, and a second conductive contact. The wavelength range of light generated by the light-emitting device may be narrowed based on the photonic cavity being included in the substrate, and the intensity and wavelength range of the generated light may be controlled based on the substrate functioning as a gate.

Light-emitting device comprising photonic cavity

An integrated circuit is provided for use in conjunction with an external antenna. The integrated circuit includes a memory circuit, a pulse sequencer, an NMR transmitter circuit and an NMR receiver circuit. The memory circuit is configured to store user-defined parameter data pertaining to an excitation period and an acquisition period that are part of an NMR pulse sequence. The pulse sequencer and the NMR transmitter circuit are configured to cooperate to generate RF signals in accordance the user-defined parameter data stored in the memory circuit, wherein such RF signals are supplied to the external antenna for emitting excitation signals from the external antenna during the excitation period of the NMR pulse sequence. The NMR receiver circuit is configured to receive electrical signals generated by the external antenna during the acquisition period of the NMR pulse sequence.

Integrated circuit for NMR systems

The Rabi frequency of oscillation of the nuclear magnetization vector of a sample in an NMR system may be controlled by modifying only the duty cycle of RF pulses delivered to the sample, without modifying the amplitude of the RF pulses, until the energy delivered at the Larmor frequency is adjusted to a desired amount. An impedance matching network between an NMR transceiver and an NMR coil may perform both power matching and noise matching simultaneously. During a transmission mode, the impedance matching network is connected to a transmitter portion of the transceiver, and the impedance of the coil is matched to the driver resistance. During a receiver mode, the impedance matching network is disconnected from the transmitter portion so that the impedance matching network remains connected only to the receiver portion, and signal-to-noise ratio in received NMR signals is maximized.

Systems and methods for design and construction of NMR transceiver circuits

Growing community of inventors

Cambridge, MA, United States of America

Donhee Ham