Promega Corporation

Dongping Ma

Poncho Meisenheimer

James J Cali

John William Shultz

Wenhui Zhou

Sarah Duellman

Jessica Kelts

Jessica Anderson

Dana Mustafa

Provided are labeling reagents and methods of using the reagents for cell uptake measurements. The labeling reagents can be quinone-masked probes including fluorophores and/or luminophores.

Quinone-masked probes as labeling reagents for cell uptake measurements

The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.

Bioluminescent assays using cyanobenzothiazole compounds

The invention provides methods that employ derivatives of 2-cyano-6-hydroxy- or 2-cyano-6-amino-benzothiazole, for example, in a bioluminogenic reaction. Also provided are novel compounds that can be used in the methods. The invention further provides methods for detecting or determining the presence of molecules and/or enzymes, the modulator activity of such molecules, and/or the activity of such enzymes. The methods are adaptable to high-throughput format.

Bioluminescent detection of cyanohydroxy benzothiazole compounds

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Madison, WI, United States of America

Dongping Ma