Walter and Eliza Hall Institute of Medical Research

Msd R&d (China) Co., Ltd.

Merck Sharp + Dohme Corp.

Merch Sharpe & Dohme LLC

Msd R&d Co., Ltd.

Dongmei Zhan

Bin Hu

John A McCauley

David Brian Olsen

Zhuyan Guo

Manuel De Lera Ruiz

Michael J Kelly, Iii

Zhiyu Lei

Lianyun Zhao

Brad Sleebs

Alan F Cowman

Paola Favuzza

Cailing Zhang

Tony Triglia

Jennifer K Thompson

John A Mccauley

Michael J Kelly Iii

Methods of treating malaria comprising administration of compounds of Formula (I') or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. It also provides uses of the compounds of Formula (I), as defined herein, for inhibiting plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

Antimalarial agents

The present invention provides methods of treating malaria comprising administration of compounds of Formula (I) or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the variables are as defined herein. The invention also provides uses of the compounds of Formula (I), as defined herein, for the possible inhibition of plasmepsin X, plasmepsin IX or plasmepsin X and IX activity, for treating ainfection, and for treating malaria. Also provided are methods of treatment further comprising administration of one or more additional anti-malarial compounds.

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Shanghai, China

Dongmei Zhan