City University of Hong Kong

Versitech, Inc.

Donglei Chen

Song Wang

Chaojian Hou

Lixin Dong

Ning Xi

Wenqi Zhang

Pengtao Liu

Zhiyong Sun

A nano scale robotic system for single cell DNA sequencing of a strand of DNA positioned on a slide utilizes an atomic force microscope (AFM) having an end effector in the form of a cantilever with a tip. The AFM causes its cantilever tip to scan over the base pairs of the DNA strand. A pair of spaced-apart electrodes at the tip makes contact with opposite sides of the DNA strand and the current between bases of the DNA strand is measured by a current measurement system connected to the electrodes. An artificial intelligence-based data analytic system determines the DNA sequence based on the current from the current measuring system. The AFM tip is guided over the DNA strand by comparing compressed desired intensity local scan images and compressed actual intensity local scan images and using the difference to control the location of the tip.

Nano robotic system for high throughput single cell DNA sequencing

Growing community of inventors

Hong Kong, China

Donglei Chen