Amgen Inc.

Donghui Shi

Zhulun Wang

Xiaoshan Min

Ian Nevin Foltz

Chadwick Terence King

Randal Robert Ketchem

Ai Ching Lim

Dirk E Smith

Rutilio Clark

Michael R Comeau

Darren L Bates

David J Lloyd

Neeraj Jagdish Agrawal

Murielle M Veniant-Ellison

Junming Yie

Christopher Murawsky

Jinghong Wang

Renee Komorowski

Brandon C P Clavette

Shu-yin Ho

Glenn N Sivits, Jr

Mark Leo Michaels

Pavel V Bondarenko

Irwin Chen

Todd Hager

Aiko Umeda

Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists

Nucleic acid molecules encoding binding proteins for gastric inhibitory peptide receptor (GIPR)

Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and deriviatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

ST2 antigen binding proteins

Described herein are compositions and methods related to antigen binding proteins that bind to human ST2, including antibodies. In particular embodiments, the disclosure provides fully human anti-ST2 antibodies and derivatives and variants thereof. Further provided are nucleic acids encoding such antibodies and antibody fragments, variants, and derivatives. Also, provided are methods of making and using such antibodies including methods of treating and preventing autoimmune and inflammatory disorders.

Growing community of inventors

Thousand Oaks, CA, United States of America

Donghui Shi