University of Washington

Koninklijke Philips Corporation N.v.

Donghoon Lee

Patrick S Stayton

Pierre D Mourad

Anthony Convertine

Richard Glen Ellenbogen

Forrest M Kievit

Julia Mengyun Xu

Menko P Ypma

Peter A Chiarelli

Joshua Sang Hun Park

Michael R Bailey

Adam D Maxwell

Vera Khokhlova

Wayne Kreider

Tatiana Khokhlova

George R Schade

Yak-Nam Wang

Navid Farr

Ari Partanen

Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.

Oxygen reactive polymers for treatment of traumatic brain injury

Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as 'boiling histotripsy' (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

Growing community of inventors

Seattle, WA, United States of America

Donghoon Lee