Generon (shanghai) Corporation Ltd.

Evive Biotechnology (shanghai) Ltd

Generon Corporation Ltd.

Evive Biotechnology Ltd

Dongdong Wu

Xiaoqiang Yan

Yuliang Huang

Cheng Yi Huang

Kaiyang Tang

Heng Liu

Zhihua Huang

Yuilang Huang

Cheng Huang

The present application provides methods of administering an IL-22 dimer to an individual, such as a human individual, comprising intravenously administering to the individual an effective amount of an IL-22 dimer, wherein the amount of the IL-22 dimer is about 2 &#x3bc;g/kg to about 200 &#x3bc;g/kg (such as about 10 &#x3bc;g/kg to about 45 &#x3bc;g/kg), as well as methods of treating diseases by following such administration methods. Also provided are kits, unit dosages, and articles of manufacture for use in any one of the methods described herein.

Use of IL-22 dimer in manufacture of a medicament for intravenous administration

The present application provides methods of administering an IL-22 dimer to an individual, such as a human individual, comprising intravenously administering to the individual an effective amount of an IL-22 dimer, wherein the amount of the IL-22 dimer is about 2 &#x3bc;g/kg to about 200 &#x3bc;g/kg (such as about 10 &#x3bc;g/kg to about 45 &#x3bc;/kg), as well as methods of treating diseases by following such administration methods. Also provided are kits, unit dosages, and articles of manufacture for use in any one of the methods described herein.

This invention discloses the uses of IL-22 in the treatment and prevention of a nerve damage disease or a neurodegenerative disease. In particular, the invention discloses the uses of IL-22 or IL-22 dimers as follows: (i) can protect neurons to recover the functions of injured neurons after ischemic nerve damage in animals in vivo, thus enabling effective treatment of nerve damage diseases, (ii) can significantly inhibit the loss of dopaminergic neurons in substantia nigra in PD model animal, enhance the functions of dopaminergic neurons, significantly reduce neuronal apoptosis in hippocampus, improve learning and memory capacity of AD model rats, and effectively prevent neuronal loss, thereby enabling more effective treatment of neurodegenerative diseases.

Uses of interleukin-22(IL-22) in treating and preventing nerve damage diseases or neurodegenerative diseases

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Shanghai, China

Dongdong Wu