Beijing Lunarsun Pharmaceutical Co., Ltd.

China Academy of Railway Sciences Corporation Limited

Locomotive & Car Research Institute of China Academy of Railway Sciences

Beijing Zongheng Electro-mechanical Technology Co., Ltd.

Dongdong Cui

Xiaobo Zhang

Jilei Gao

Tianxiang Zhang

Qipei Qiu

Shuquan Song

Kai Huang

Weizhi Liu

Shuichang Li

Zhenhuan Yin

Wen Chen

Xinyuan Dong

Disclosed are a new S crystal form of ivabradine hydrochloride, and preparation method and pharmaceutical composition thereof. The S crystal form of ivabradine hydrochloride has a powder diffraction pattern having characteristic peaks at degrees two-theta positions of 8.5&#xb1;0.2, 11.5&#xb1;0.2, 14.6&#xb1;0.2, 15.3&#xb1;0.2, 16.1&#xb1;0.2, 17.1&#xb1;0.2, 17.4&#xb1;0.2, 17.8&#xb1;0.2, 18.6&#xb1;0.2, 19.3&#xb1;0.2, 21.6&#xb1;0.2, 21.9&#xb1;0.2, 27.2&#xb1;0.2, and, by DSC measurement, has an endothermic crystal transformation peak as a characteristic peak at 111.6&#xb0; C. and an exothermic crystal transformation peak as a characteristic peak at 136.9&#xb0; C., and a melting decomposition peak as a characteristic peak at 194.9&#xb0; C. The S crystal form products are easy to dry, have high purity and stability, and are convenient for long-term storage without particular temperature and humidity requirements. The preparation method thereof facilitates industrial production, and has great application value and market value.

S-crystal form of ivabradine hydrochloride, and preparation method and pharmaceutical composition thereof

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Beijing, China

Dongdong Cui