Hoffmann-la Roche Inc.

Kind Pharmaceutical

Other

F. Hoffmann-la Roche Ag

Dongdong Chen

Song Feng

Chao Li

Hongying Yun

Lu Gao

Lisha Wang

Xiufang Zheng

Dong Liu

Baoxia Wang

Biao Deng

Xiangyun Tu

Zinan Fang

Haohao Wu

Danyan Gu

Hong Shen

Xuefei Tan

Yongfu Liu

Wei Zhu

Jun Wu

Li Ping Wang

Li Wang

Fabian Dey

Chungen Liang

Guolong Wu

Haixia Liu

Min Jiang

Kun Miao

Hongtao Xu

Ge Zou

Wenming Chen

Dong Ding

Qinghong Chen

John Dunlop

Jiamin Zheng

The present invention relates to compounds of formula (I), wherein Rto Rand n are as described herein, and their pharmaceutically acceptable salt thereof, and compositions including the compounds and methods of using the compounds.

Hydro-1H-pyrrolo[1,2-a]pyrazine compounds for the treatment of autoimmune disease

The present invention provides flavone derivatives having the general formula (I) which are useful for the treatment of Hepatitis B Virus infection (HBV). The compounds act as cccDNA (covalently closed circular DMA) inhibitors.

Flavone compounds for the treatment and prophylaxis of hepatitis B virus disease

This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine.

Indolizine derivatives and their application in medicine

The present invention provides novel compounds having the general formula (Formula I): wherein Rto R, G, G, Ato Aand m are as described herein, compositions including the compounds and methods of using the compounds.

Flavone derivatives for the treatment and prophylaxis of hepatitis B virus disease

This invention relates to indolizine derivatives and their use in medicine. In particular, the present invention discloses novel substituted indolizine derivatives of formula I, or an isotopically labeled compound thereof, or an optical isomer thereof, a geometric isomer thereof, a tautomer thereof or a mixture of various isomers, or a pharmaceutically acceptable salt thereof, or a prodrug thereof. The invention also relates to the use of these compounds in medicine. 

The present invention relates to compounds of formula (I), wherein R, Rand Rare as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Process for making 3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2, 7-dione compounds useful for the treatment of virus infection

An electrical enclosure with a great heat dissipation and an ingress protection rating equal or greater than level 65, including a sealed enclosure housing and a heat bridge configured inside the sealed enclosure housing. The sealed enclosure housing includes a heat-absorbing layer, a reinforced layer and a heat dissipating layer. The heat bridge can be a gaseous heat bridge or a solid heat bridge. One end of the heat bridge is connected to the heat-emitting electrical components configured inside the sealed enclosure, and the other end is connected to the heat-absorbing layer on the sealed enclosure housing. The generated heat is rapidly conducted to the heat-absorbing layer on the enclosure housing through the heat bridge, and then conducted to the heat dissipation layer through the reinforced layer. The heat is dissipated to the exterior space through such structure to keep a suitable temperature inside the sealed enclosure.

Electrical enclosure with a great heat-dissipation and an ingress protection rating equal or greater than level 65

A method of promoting muscle growth consisting of providing a dietary supplement containing an effective amount of dehydroandrosterol to a user. A composition for promoting muscle growth containing an effective amount of dehydroandrosterol.

Dehydroandrosterol and methods of using the same

3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2, 7-dione compounds for the treatment and prophylaxis of virus infection

The present invention provides novel compounds having the general formula: 

Xanthone derivatives for the treatment of hepatitis B virus disease

3-substituted 5-amino-6H-thiazolo[4,5-d]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection

The present invention relates to compounds of formula (I), wherein R, R, R, R, Rand Rare as described herein, and their prodrugs or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Compounds for the treatment of infectious diseases

3-substituted 5-amino-6H-thiazolo[4,5-D]pyrimidine-2,7-dione compounds for the treatment and prophylaxis of virus infection

Growing community of inventors

Shanghai, China

Dongdong Chen