University of Michigan

Ascentage Pharma (suzhou) Co., Ltd.

Ascentage Pharma Group Corp Limited

Dongbo Li

Shaomeng Wang

Chao-Yie Yang

Wenming Chen

Yunlong Zhou

Yu Jing

Chao Li

Hao Chen

Guozhi Tang

Liugen Li

Xianchan Zha

Provided are compounds represented by Formula IA: (IA), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, L, L, L, X, A, B and C are as defined as set forth in the specification. Also provided compounds of Formula IA for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Macrocyclic fused pyrazoles as Mcl-1 inhibitors

Disclosed is compound of formula I and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, L, L, #, #, # are as defined as set forth in the re) specification. Disclosed is compound of formula I for use to treat a condition or disorder responsive to Mcl-1 inhibition such as cancer.

Macrocyclic indoles as Mcl-1 inhibitors

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Suzhou, China

Dongbo Li