Glaxosmithkline Biologicals Sa

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Dong Yu

Mayuri Sharma

Barney S Graham

Wing-Pui Kong

John Mascola

Padma Malyala

Theodore C Pierson

Kimberly A Dowd

Marcelo Samsa

Olga Slack

Alan Stokes

Sung-Youl Ko

Kathryn Hashey

Rashmi Jalah

Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen.

Zika viral antigen constructs

Nucleic acid based vaccine constructs encoding Lyssaviral antigens are useful in preventing and treating diseases. Self-amplifying RNA molecules encoding Lyssaviral antigens provide potent and long-lasting immunity.

Lyssavirus antigen constructs

Compounds useful as components of immunogenic compositions for the induction of an immunogenic response in a subject against viral infection, methods for their use in treatment, and processes for their manufacture are provided herein. The compounds comprise a nucleic acid construct comprising a sequence which encodes a Zika virus antigen. A particular embodiment is a nucleic acid-based vaccine construct encoding a polypeptide comprising a full-length Zika virus prME antigen. A particular embodiment is a self-replicating RNA molecule comprising a construct encoding a polypeptide comprising a full-length Zika virus prME antigen.

Growing community of inventors

Rockville, MD, United States of America

Dong Yu