Siemens Aktiengesellschaft

Jiangsu Alphamab Biopharmaceuticals Co., Ltd.

Dong Yang

Ting Xu

Xiaoxiao Wang

Pilin Wang

Yuhao Jin

Kangping Guo

Deng Ke Zhang

Harald Krieger

Qing Li

Qing Ping Li

The present disclosure provides a dimer formed by two polypeptide chains, with each of the two polypeptide chains comprising an antibody Fc subunit, wherein the dimer comprises two or more immunoglobulin single variable domains (ISVDs), at least one of the ISVDs is specific for PD-L1, and at least one of the ISVDs is specific for CTLA4.

Dimers and use thereof

Disclosed is a handle locking device, including a first frame, a first snap hook and a second frame. A second snap hook is provided on the first frame; the first snap hook is rotatably mounted on the first frame; the second frame is rotatably mounted on the first frame; a protruding portion is formed on the second frame; and the protruding portion can push the first snap hook towards the first frame. By having the first snap hook and second snap hook disposed asymmetrically on the first frame, accidental mounting of the 'OFF' position of the handle locking device in the 'ON' position of the circuit breaker during installation by an operator can be avoided. Moreover, since the protruding portion can push the first snap hook towards the first frame, forced deformation of the snap claw and second snap hook can be prevented.

Circuit breaker and handle locking device thereof

Disclosed is a handle locking device including a first frame, a first hook and a second frame, wherein a second hook is provided on the first frame. The first and second hooks are rotatably installed on the first frame, and the second frame capable of fixing the first hook and the first frame. Since the handle locking device is only be installable on a circuit breaker by mating between the first hook and a first installation part of the circuit breaker and mating between the second hook and a second installation part of the circuit breaker, an operator is prevented from unintentionally setting an 'OFF' position of the handle locking device in an 'ON' position of the circuit breaker during installation. The first hook is rotatably installed on the first frame, so that the handle locking device can be conveniently and rapidly installed on or demounted from the circuit breaker.

Growing community of inventors

Suzhou, China

Dong Yang