Genentech, Inc.

Dong-Xiao Zhang

Paul J Godowski

William I Wood

Jian Chen

Melanie Rose Mark

The invention concerns a novel neuregulin related ligand (NRG3) including fragments and variants thereof, as new members of the neuregulin family of compounds. The invention also concerns methods and means for producing NRG3. The native polypeptides of the invention are characterized by containing an extracellular domain including an EGF-like domain, a transmembrane domain and a cytoplasmic domain. Isolated nucleotide sequences encoding such polypeptides, expression vectors containing the nucleotide sequences, recombinant host cells transformed with the vectors, and methods for the recombinant production for the novel NRG3s are also within the scope of the invention.

ErbB4 receptor-specific neuregulin related ligands and uses therefor

The invention concerns a novel human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The novel interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the novel polypeptide, and methods and means for their recombinant production are also included.

Human interferon-&egr;: a type I interferon

The invention concerns a human interferon-&egr;, originally designated PRO655, and its variants and derivatives. The interferon is related to but distinct from members of the IFN-&agr; family and from IFNs-&bgr; and -&ggr;. Nucleic acid encoding the polpypeptide, and methods and means for their recombinant production are also included.

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Burlingame, CA, United States of America

Dong-Xiao Zhang