University of Nebraska

Huntsman Advanced Materials Americas LLC

University of Utah Research Foundation

Hospital for Special Surgery

Dong Wang

Zhenshan Jia

Xiaobei Wang

Fang Yuan

Derek Scott Kincaid

Scott Corey Miller

Jindrich Henry Kopecek

Pavla Kopeckova

Rongguo Ren

Bradley Rechichar

Dong Le

Irving H Zucker

Hanjun Wang

Ronald C Smith, Jr

Xin-Ming Liu

Steven R Goldring

Derek Kincaid

Steven Lisco

Yosif Almoshari

Ningrong Chen

Gang Zhao

Xin Wei

Thomas Nicholas

K P Subrahmanian

Michael Lankhorst

Lie Gao

Juan Hong

Matthew Kelso

Pavla Kopecková

Wenfeng Kuang

Leo Arguelles

Edward V Fehringer

Derek S Kincaid

This application discloses prodrug-based thermosensitive gel ('ProGel') comprised of conjugates of dmg molecules with water-soluble polymeric carriers, which are capable of controlled release of the dmg molecules into the tissue of a subject. Use of the ProGel-Drug conjugates for treatment of various diseases or disorders and methods of preparing them are also disclosed.

Macromolecular prodrug-based thermosensitive injectable gel as a novel drug delivery platform

Disclosed is a hydrogel drug delivery composition comprising a therapeutic agent and a poloxamer, wherein the poloxamer is modified to be capable of adhering to a surface of bones or teeth, and wherein the poloxamer is modified by pyrophosphate, bisphosphonates, acidic peptides or tetracycline and its derivatives.

Hydrogel drug delivery composition

Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases or disorders are provided. In accordance with the instant invention, methods of inhibiting, treating, and/or preventing peripheral artery disease or symptoms associated therewith are provided. In a particular embodiment, the methods inhibit, treat, and/or prevent claudication associated with peripheral artery disease.

Compositions and methods for the treatment of peripheral artery disease and cardiopulmonary diseases

Polyethylene glycol (PEG)-conjugated glucocorticoid prodrugs, methods of preparation, and use for the treatment of diseases and disorders are disclosed. In particular, PEG-conjugated dexamethasone compounds and methods of using them for treating inflammatory and autoimmune diseases, including but not limited to lupus, are disclosed.

Polyethylene glycol-conjugated glucocorticoid prodrugs and compositions and methods thereof

The present disclosure provides a curable composition containing a benzoxazine, reactive diluent and a soluble polyimide. The curable composition, upon curing, renders an article having well balanced thermal, chemical and mechanical properties and may be used in a variety of applications, such as in coatings, structural composites and encapsulating systems for electronic and electrical components.

Curable benzoxazine compositions

The present disclosure provides an organic sulfur acid-free composition containing a benzoxazine, phenolic compound and nitrogen-containing heterocyclic compound. The organic sulfur acid-free composition, upon curing at temperatures as low as 130&#xb0;-140&#xb0; C., renders void free cured articles having well balanced thermal, chemical and mechanical properties. The organic sulfur acid-free composition may be used in a variety of applications, such as in coatings, structural and non-structural composites and encapsulating systems for electronic and electrical components.

Benzoxazine low temperature curable composition

This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

Macromolecular delivery systems for non-invasive imaging, evaluation and treatment of arthritis and other inflammatory diseases

Drug carriers, methods of synthesizing, and methods of use thereof are provided. The drug carriers are liposomes comprising at least one functionalized cholesterol of the formula: Chol-X-T, wherein X is a linker domain, T is at least one targeting moiety which binds hard tissue and/or medical implants, and Chol is cholesterol or a derivative or analog thereof. The liposomes may encapsulate at least one therapeutic agent for the treatment of an oral disease or disorder.

Biomineral and metal binding liposomes, their synthesis, and methods of use thereof

Compositions and methods for the inhibition and/or prevention of traumatic brain injury and the symptoms associated with it are provided.

Compositions and methods for the treatment of traumatic brain injury

The present disclosure provides a method for producing a benzoxazine compound by reacting a bi-functional phenol with formaldehyde and a mono-functional amine in the presence of a solvent system containing an apolar solvent and a polar aprotic solvent. Once formed, the benzoxazine compound may be precipitated from the reaction solution and dried to form a benzoxazine compound in powder form.

Method for producing benzoxazine compounds

Growing community of inventors

Omaha, NE, United States of America

Dong Wang