Neuracle Science Co., Ltd.

Lg Electronics Inc.

Other

Lubrizol Advanced Materials, Inc.

Neuracle Genetics Inc.

Dong Sik Kim

Bongcheol Kim

Jae-Keun Lee

Soon-gu Kwon

Juwon Shim

Dong Kwan Kim

Tae Woong Lee

Young Woo Kim

Myeong Su Jeong

Hwa Yong Lee

Tae Ki Shin

Kyung Soo Kim

Dong Woo Lee

Junho Chung

Jong-Mook Kim

Jae Young Seong

Dae Hyung Lee

Eun Bee Cho

Junyeong Jin

Shin-Hyuk Kang

Seong Hwan Seo

Beom Jim Kim

Nam Jung Kim

Dong Heon Han

Jung Ryeol Kim

Tae Woo Kim

The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a retinopathy (e.g., diabetic retinopathy) and/or maculopathy (e.g., age-related macular degeneration) in a subject in need thereof.

Use of anti-FAM19A5 antibodies

The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat an atherosclerosis in a subject in need thereof.

Use of anti-FAM19A5 antibodies for treating atherosclerosis

The present disclosure provides adeno-associated vims (AAV) vectors and uses thereof. In certain embodiments, the AAV vectors comprise a nucleic acid that encodes an antagonist against a family with sequence similarity 19, member A5 (FAM19A5) protein, e.g., anti-FAM19A5 antibody, e.g., anti-FAM19A5 scFv.

Adeno-associated virus (AAV) delivery of anti-FAM19A5 antibodies

The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat or to diagnose a fibrosis and/or a fibrosis-associated disease in a subject in need thereof.

Use of anti-FAM19A5 antibodies for treating fibrosis

The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to treat a glaucoma in a subject in need thereof.

Use of anti-family with sequence similarity 19, member A5 antibodies for the treatment of glaucoma

The present disclosure provides a method for the treatment of a neuropathic pain including a central neuropathic pain or a peripheral neuropathic pain in a subject comprising the administration of antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. The present disclosure also provides methods for treating a neuropathic pain including a symptom of neuropathic pain, and/or an underlining cause of a neuropathic pain, by administering an antibody that specifically binds to human FAM19A5. In a specific aspect, the method comprises administering antibodies specifically bind to human FAM19A5, e.g., binds to soluble human FAM19A5 with a Kof 10 nM or less, or binds to membrane bound human FAM19A5 with a Kof 10 nM or less, or both, as measured by a method known in the art, e.g., ELISA.

Use of anti-family with sequence similarity 19, member A5 antibodies for the treatment of neuropathic pain

The present disclosure provides antibodies that specifically bind to human FAM19A5 and compositions comprising such antibodies. Also provided herein are methods for treating fibrosis or cancer using the anti-FAM19A5 antibodies.

Anti-FAM19A5 antibodies and uses thereof

The present disclosure relates to the pharmaceutical use of antagonists (e.g., an antibody or antigen-binding portion thereof) that specifically bind to FAM19A5 to promote a blood vessel normalization and treat a disease (e.g., cancer) in a subject in need thereof, e.g., by promoting a blood vessel normalization.

Use of anti-FAM19A5 antibodies for treating cancers

The present invention relates to an adaptor for a slit lamp microscope. According to one embodiment of the present invention, the invention provides the advantages of: facilitating the maintenance/repair of a slit lamp microscope since a camera member used for the slit lamp microscope is simply attached or detached; simply and easily inspecting and photographing a subject's eye; and obtaining a high-resolution video or image for the subject's eye at low costs.

Adaptor for slit lamp microscope

Provided is an IV flow controller which adjusts the amount of an IV material supplied to a patient through an IV tube and to which a flushing feature is added. The IV controller according to the present invention includes: a first body unit, a second body unit, a fixed roller, and a driving roller. The fixed roller is fixedly and rotatably arranged, and has a first gear unit and a second gear unit. The driving roller is accommodated such that a portion thereof is exposed, and the driving roller is moved along the lengthwise direction while controlling the flow of the IV when the exposed portion is turned. Also, in the flushing position, the driving roller rotates in cooperation with the first gear unit of the fixed roller across the IV tube so as to flush the latter. The second gear unit of the fixed roller may be configured so as to have a ratchet gear, and the second body unit has a pawl which meshes with the ratchet gear of the fixed roller in order to prevent reverse rotation. According to the present invention, flushing in the reverse direction is prevented by the ratchet gear, and thus medical accidents caused by reverse flushing can be prevented.

IV flow controller having flushing feature

A broadcast receiver and method of providing a preferred channel thereof are disclosed. The present invention includes receiving a program of the preferred channel () set by a user among a plurality of broadcast channels, transforming an image of the received program of the preferred channel into a reduced image () and storing the reduced image per the preferred channel. Accordingly, when a turn-on mode of the broadcast receiver is switched to a turn-off mode () of the broadcast receiver, when a turn-off mode () of the broadcast receiver is switched to a turn-on mode of the broadcast receiver, or when a display of a preferred channel is requested in a turned-on mode, a per preferred channel reduced image is displayed as OSD () on a currently viewed image. So, a user is facilitated to recognize and select a program received on the preferred channel without blocking the currently viewed image.

Broadcast receiver and method of providing preferred channel thereof

Disclosed is a transparent multilayer sheet that is excellent in antistatic properties, as well as transparency. The transparent multilayer sheet includes a surface layer comprising a conductive thermoplastic polyurethane or polyurea resin containing ethylene oxide; and a back layer attached to the surface layer and comprising a transparent non-conductive polymer resin. Preferably, the polyurethane or polyurea resin is a polymerization product of (a) a polyether-based polymer containing ethylene oxide and reacting with an isocyanate group; (b) an aromatic or aliphatic diisocyanate compound; and (c) a chain extender C2 to C10 containing a primary hydroxyl group or an amine group, and the transparent non-conductive polymer resin is selected from the group consisting of polyethylene terephthalate, glycol modified polyethylene tereph-thalate, glycol modified polycyclohexaneterephthalate, polymethylmethacrylate, polycarbonate, transparent acrylonitrile-butadiene-styrene (ABS), and mixtures thereof.

Transparent multilayer sheet having electrostatic dissipative properties

Disclosed is a halogen-free flame retardant thermoplastic polyurethane composite resin composition. The disclosed flame retardant thermoplastic polyurethane composite resin composition is capable of improving flame retardancy and flaming-drip of a thermoplastic polyurethane resin through desirable formation of char during combustion, which uses a phosphinate, a diphosphinate and/or a polymer thereof, dipentaerythritol, talc, a melamine derivative, etc., instead of a halogen-based flame retardant, as a flame retardant.

Halogen-free flame retardant thermoplastic polyurethanes

A method and device for determining the presence or absence of a disk and/or a disk size without using FG signals, are provided. The method includes placing a pickup at a first zone on the optical recording medium, the first zone located between an outer radius of a first recording medium type and an outer radius of a second recording medium type, where the outer radius of the second recording medium type is larger than the outer radius of the first recording medium type; detecting a reflected signal based on a returned beam from the first zone of the optical recording medium; and determining at least one of a size and an absence of the optical recording medium based on the detected reflected signal. Therefore, an FG sensor that is provided in a general disk device can be eliminated, thereby reducing the size and cost of a disk device.

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Seoul, South Korea

Dong Sik Kim