Oscotec Inc.

Genosco

Oscotech Inc.

Dong-Sik Jung

Jung-Ho Kim

Se-Won Kim

Jang-Sik Choi

Jaekyoo Lee

Yung-Geun Choi

Sung-Ho Park

Hee Kyu Lee

Jong-Sung Koh

Song-Eun Park

In Y Lee

Jong Sung Koh

Byung-Chul Suh

Ho-Juhn Song

Paresh Salgaonkar

Jaesang Lee

Hae-Jun Hwang

Se-Nyum Kim

Dae-Pil Kang

Youn Ho Han

Guo Fan Jin

Ji Min Kim

Jhi Zheng

Tae-Im Lee

Jung Ho Kim

Hwa Sil Kim

In Yong Lee

Paresh Devidas Salgaonkar

Pyridopyrimidinone derivatives and pharmaceutical compositions containing the same for use as an Axl inhibitor for the treatment of a disease or condition mediated by Axl such as cancer and metastasis, are disclosed. Also disclosed are methods for treating a Axl-mediated disease or condition by administering to a subject a therapeutically effective amount of the pyridopyrimidinone derivative.

Pyridopyrimidinone derivatives for use as AXL inhibitors

An embodiment relates to a crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido [4,3-d]pyrimidin-5(6H)-one hydrochloride which can effectively suppress FLT3 and has excellent stability even in a high temperature and humid environment, and a method for preparing same.

Crystal polymorph of 8-bromo-2-(1-methylpiperidin-4-ylamino)-4-(4-phenoxyphenylamino)pyrido[4,3-d]pyrimidin-5(6H)-one hydrochloride and method for preparing same

A pyrrolo(pyrazolo)pyrimidine compound of Formula 1, a pharmaceutically acceptable salt, a hydrate, a solvate, a prodrug, and an isomer, and pharmaceutical compositions containing the compound are disclosed. The compound of Formula 1 shows excellent LRRK2 inhibitory activity. Method for manufacturing the compound and uses thereof as an LRRK2 inhibitor and methods for treating or preventing degenerative brain diseases employing the compound are disclosed: 

Substituted pyrazoles as LRRK2 inhibitors

Compounds of Formula (I) and methods for inhibiting kinases, including spleen tyrosine kinases, are disclosed. Also disclosed are methods for treating a kinase-mediated disease or condition by administering to a subject a therapeutically effective amount of the compound of Formula (I). 

Substituted pyrimidine compounds and their use as SYK inhibitors

The present invention relates to an alpha-arylmethoxyacrylate derivative, a preparation method thereof and a pharmaceutical composition comprising the same, and the alpha-arylmethoxyacrylate derivative is inhibitory of HIF, which plays an important role in the regulation of genes associated with energy metabolism, vasomotion, angiogenesis and apoptosis and in the response of cells under hypoxic conditions, so that it can be used for preventing or treating of diseases such as cancer, arthritis, psoriasis, diabetic retinopathy and macular degeneration.

Alpha-arylmethoxyacrylate derivative, preparation method thereof, and pharmaceutical composition containing same

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Cheonan-si, South Korea

Dong-Sik Jung