Ahn-gook Pharmaceutical Co., Ltd.

Incheon University Industry Academic Cooperation Foundation

Bamichem Co., Ltd.

Dong-Oh Han

Jin Auh

Sung-Min Kim

Jong-Wook Lee

Chang-Hwan Kim

Chang-Kyun Han

Cheol Han

Soon Kil Ahn

Young-June Shin

Nam Song Choi

Sung-Hum Yeon

Soo-Im Chang

Hyo-Jin Moon

Tae-jeong Kim

Ji-Hye Lee

Jun-Seok Lee

Kamsa Pae

Ho-Young Kwak

Chang Kyun Han

Young June Shin

Seung-In Choe

Cheol Kyu Han

Tae-Jeong Kim

The present invention relates to a novel compound or a pharmaceutically acceptable salt thereof inhibiting 11&#x3b2;-HSD1 enzyme activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. Since the compound of the present invention selectively inhibits the activity of 11&#x3b2;-HSD1 (11&#x3b2;-Hydroxysteroid dehydrogenase type 1), the compound of the invention can be effectively used as a therapeutic agent for the treatment of diseases caused by the over-activation of 11&#x3b2;-HSD1 such as non-insulin dependent type II diabetes, insulin resistance, obesity, lipid disorder, metabolic syndrome, and other diseases or condition mediated by the excessive activity of glucocorticoid.

Compound having ability to inhibit 11Beta-HSD1 enzyme or pharmaceutically acceptable salt thereof, method for producing same, and pharmaceutical composition containing same as active ingredient

The present invention relates to a novel use of herbal extracts in a pharmaceutical composition for prevention and treatment of nephritis and, more particularly, to a pharmaceutical composition and a health functional food for prevention and/or treatment of nephritis that contains at least one herbal extract selected from the group consisting of a Crataegi Fructus extract, a Cinnamomi Cortex extract, a Prunella Spica extract, and an Equiseti Herba extract, a method for prevention and/or treatment of nephritis using the herbal extract, and a use of the herbal extract in preparation of a composition for prevention and/or treatment of nephritis. The herbal extract has a good therapeutic effect for nephritis on a nephritis model of which the nephritis is induced by a drug such as gentamicin, cisplatin, etc., and a good inhibitory activity on the growth of mesangial cells in kidneys, thereby providing a very useful means for prevention and/or treatment of nephritis.

Pharmaceutical composition containing herbal extract for prevention or treatment of nephritis

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Anyang-si, South Korea

Dong-Oh Han