Abl Bio Inc.

Korea Advanced Institute of Science and Technology

Dong In Kim

Kyung Duk Moon

Dong Heon Lee

Yu Bin Choi

Kyung Jae Kang

Sang Yup Lee

Tong Un Chae

Sang Kyung Park

JinWon Jung

Eun A Kim

Jin Hyung Ahn

Weon Kyoo You

Jinwon Jung

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Disclosed is a method of preparing primary amines. More particularly, disclosed are a mutant microorganism transformed with a gene encoding a valine decarboxylase and a method of preparing primary amines from amino acids using the mutant microorganism. The method has an effect of synthesizing, in an environmentally friendly manner, primary amines as precursors for pharmaceuticals and agricultural chemicals using microorganisms, as an alternative to conventional chemical synthesis methods.

Method of preparing primary amines from amino acids using enzymatic conversion

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The present invention relates to a novel dual-targeting protein comprising: a protein that binds specifically to delta-like ligand 4 (DLL4); and an antibody that binds specifically to vascular endothelial cell growth factor (VEGF).

Dual-targeting protein binding specifically to DLL4 and VEGF and use thereof

The present invention relates to a novel monoclonal antibody that binds specifically to delta-like ligand (DLL4), and more particularly to a monoclonal antibody that binds specifically to human delta-like ligand 4 to effectively inhibit the interaction between delta-like ligand 4 and Notch receptor, a polynucleotide encoding the monoclonal antibody, an expression vector comprising the polynucleotide, a transformant comprising the expression vector, a method for preparing the monoclonal antibody, a pharmaceutical composition for preventing or treating cancer comprising the monoclonal antibody, a composition for diagnosing cancer comprising the monoclonal antibody, a method for diagnosing cancer using the monoclonal antibody, and a pharmaceutical composition for preventing or treating autoimmune disease comprising the monoclonal antibody.

Monoclonal antibody binding specifically to DLL4 and use thereof

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Daejeon, South Korea

Dong In Kim