Korea Institute of Science and Technology

Dong Ho Woo

ChangJoon Justin Lee

Eun Mi Hwang

Soo Jin Oh

Jung-Eun Park

Kye-Jung Shin

Eun-Joo Roh

Dong-Gyu Kim

Wan-Keun Ji

Yun-Soo Na

Soon-Hyouk Lee

Jeong Eun Yang

Hee-jung Chun

The present invention relates to a novel phenoxypropanol derivative, represented by the structure of Chemical Formula I, and a racemate thereof, a pharmaceutically acceptable salt thereof, a solvate thereof and a hydrate thereof,  wherein * represents an (R)-form or an (S)-form, X is selected from the group consisting of hydrogen, halogen and substituted or unsubstituted straight or branched alkyl having 1 to 4 carbon atoms, and n represents the number of X and an integer of 1 to 5, wherein at least a hydrogen is substituted with halogen in the substituted linear or branched alkyl having 1 to 4 carbon atoms. The derivative can be used for blocking T-type calcium channel and/or TREK channel, and for preventing and/or treating T-type calcium channel- and/or TREK channel-associated diseases.

Phenoxypropanol derivative and pharmaceutical composition including the same

The present invention investigate the two modes of glutamate release and the releasing rate of glutamate, and thus can provide a useful technique for neuron protection and acceleration of neurotransmission by controlling the glutamate release in astroctye. Thus, the present invention provides an inhibitor of the fast-mode release and/or the slow-mode release of astrocytic glutamate, a screening method of the inhibitor and a pharmaceutical composition or method of ameliorating, preventing and/or treating the disease associated with the over-release of glutamate via the Ca-activated anion channel, with the inhibition of fast-mode glutamate release.

Method for screening a glutamate release inhibitor in an astrocyte

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Seoul, South Korea

Dong Ho Woo